Results 41 to 50 of about 67,891 (311)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Combination formoterol and inhaled steroid versus beta(2)-agonist as relief medication for chronic asthma in adults and children (Review) [PDF]

, 2009
Background Formoterol has a fast onset of action and can therefore be used to relieve symptoms of asthma. A combination inhaler can deliver formoterol with different doses of inhaled corticosteroid; when used as a reliever both drugs will be delivered ...
Adams, Balanzat, Berggren, Bisgaard, Bisgaard, Bleecker, Bousquet, British Thoracic Society, Bruce, Buhl, Buhl, Cates, Christopher, Greenstone, Haahtela, Haahtela, Higgins, Higgins, Ind, Johansson, Jonkers, Kuna, Kuna, Lundborg, Ni Chroinin, O'Byrne, O'Byrne, O'Byrne, O'Byrne, O'Byrne, Palmqvist, Price, Price, Rabe, Rabe, Rabe, Richter, Salpeter, Scicchitano, Sears, Sovani, Stallberg, Tattersfield, Tattersfield, Vogelmeier, Vogelmeier, Walters   +46 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma [PDF]

, 2010
Background Formoterol is a long-acting beta(2)-agonist but because it has a fast onset of action it can also be used as a relief medication. Objectives To asses the efficacy and safety of formoterol as reliever therapy in comparison to short-acting ...
Cates, CJ, Welsh, EJ
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Misuse of Respiratory Inhalers Among Hospitalized Patients in a Tertiary Health Care Hospital in Kabul

International Journal of COPD, 2023
Ershad Ahmad Mushkani,1 Fahima Hamidy,2 Tawfiq Ahmad,3 Mohammad Asef Adelyar4 1Department of Pharmacology, Kabul University of Medical Sciences, Kabul, Afghanistan; 2Department of Nursing Skills, Aliabad Teaching Hospital, Kabul University of Medical ...
Mushkani EA, Hamidy F, Ahmad T, Adelyar MA   +3 more
doaj  

Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis [PDF]

, 2015
Objectives: We aimed to assess the association between long-term use of inhaled corticosteroids (ICS) and bone adverse effects in patients with asthma. Design: Systematic review and meta-analysis of fracture risk and changes in bone mineral density with ...
Agertoft, Allen, Bahceciler, British-Thoracic-Society/Scottish-Intercollegiate-Guidelines-Network, El, Ferguson, Harris, Higgins, Higgins, Ioannidis, Johannes, Jones, Kelly, Kemp, Law, Li, Loke, Loke, Maspero, National-Asthma-Education-and-Prevention-Program, Ricciardolo, Richy, Rossi, Roux, Schlienger, Sosa, The Childhood Asthma Management Program Research Group, Turpeinen, Van Staa, Vanfleteren, Weatherall, Wisniewski, Yanik   +32 more
core   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Implementation of process technology and diversification of Astiri Oil products to improve community economy

Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang
Jatijejer Village, located between the slopes of Mount Penanggungan and Mount Welirang, has significant potential for cultivating aromatic plants, particularly lemongrass (Cymbopogon citratus) and citronella (Cymbopogon nardus).
Marisca Evalina Gondokesumo, Azminah Azminah, Bobby Ardiansyahmiraja, Dwie Retna Suryaningsih   +3 more
doaj   +1 more source