Results 41 to 50 of about 68,339 (362)

Misuse of Respiratory Inhalers Among Hospitalized Patients in a Tertiary Health Care Hospital in Kabul

International Journal of COPD, 2023
Ershad Ahmad Mushkani,1 Fahima Hamidy,2 Tawfiq Ahmad,3 Mohammad Asef Adelyar4 1Department of Pharmacology, Kabul University of Medical Sciences, Kabul, Afghanistan; 2Department of Nursing Skills, Aliabad Teaching Hospital, Kabul University of Medical ...
Mushkani EA, Hamidy F, Ahmad T, Adelyar MA   +3 more
doaj  

Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease [PDF]

, 2010
Background Combination therapy (inhaled corticosteroids and long-acting beta(2)-agonists) and tiotropium are both used in the treatment of chronic obstructive pulmonary disease (COPD).
Appleton, Appleton, Appleton, Barr, Bateman, Calverley, Effing, Jones, Karner, Keene, Kesten, Lacasse, Nannini, Nannini, Nannini, Singh, Singh, Suissa, Suissa, Tashkin, Yang   +20 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease [PDF]

, 2013
The aim of the study was to characterize pharmacokinetics of tiotropium solution 5 µg compared to powder 18 µg and assess dose-dependency of tiotropium solution pharmacodynamics in comparison to placebo.
Cornelissen, PJG, Derom, Eric, Disse, B, Hohlfeld, JM, Peterkin, V, Sharma, A, Towse, L, van Noord, JA   +7 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Suboptimal Control of Asthma Among Diverse Patients: A US Mixed Methods Focus Group Study

Journal of Asthma and Allergy, 2022
Maureen George,1 Zaneta Balantac,2 Chris Gillette,3 Nabeel Farooqui,4 Tommi Tervonen,5 Caitlin Thomas,5 Ileen Gilbert,6 Hitesh Gandhi,6 Elliot Israel7 1School of Nursing, Columbia University, New York, NY, USA; 2Patient-Centered Research, Evidera, San ...
George M, Balantac Z, Gillette C, Farooqui N, Tervonen T, Thomas C, Gilbert I, Gandhi H, Israel E   +8 more
doaj  

Possibility of lipid microsphere-encapsulated Y-24180 as an injectable drug and an inhaler for the treatment of bronchoconstriction

Allergology International, 2000
Y-241 80 ((±)-4-(2-chloro-phenyl)-2-[2-(4-isobuthyl- phenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2f][1,2,4] triazolo[4,3-a)[1,4]diazepine) is a lipophilic platelet- activating factor (PAF) antagonist.
Mitsuko Takenaga, Rie Igarashi, Yutaka Mizushima   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Challenging Social Cognition Models of Adherence:Cycles of Discourse, Historical Bodies, and Interactional Order [PDF]

, 2015
Attempts to model individual beliefs as a means of predicting how people follow clinical advice have dominated adherence research, but with limited success.
Alexander F., Atkinson J. M., Bowker G., Charlotte Salter, Charmaz K., Christensen A. J., Cornwell J., Department of Health, Dunbar F., Duranti A., Fairclough N., Fiona Poland, Goffman E., Hymes D., Jamie Murdoch, Jane Cross, Maimonides M., McLeod C., Mishler E. G., Osler W., Peyrot M., Salter H. H., Scollon R., Silverman D., Sontag S.   +24 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source