Animal Models and Experimental Medicine, EarlyView.We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang +14 more
wiley +1 more source
Cognitive impairment according to Montreal Cognitive Assessment independently predicts the ability of chronic obstructive pulmonary disease patients to maintain proper inhaler technique. [PDF]
BMC Pulm Med, 2023 Iamthanaporn C +2 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Mouse metabolic and behavioral phenotypes are tightly linked to strain, age and disease state, with distinct dysregulation in each disease model, underscoring the need for standardized preclinical experimental conditions. Abstract Background Metabolic and behavioral traits in mice exhibit substantial variability across strains, ages, and disease states,
Jiacheng Zeng +17 more
wiley +1 more source
Impact of Pharmacist Education on Inhaler Technique and Adherence in an Outpatient Clinic. [PDF]
Hosp Pharm, 2022 Mayzel B, Muench S, Lauster C.
europepmc +1 more source
Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs
The Anatomical Record, EarlyView.Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy +3 more
wiley +1 more source
The Inhaler Technique Questionnaire (InTeQ): Development and Validation of a Brief Patient-Reported Measure. [PDF]
Int J Environ Res Public Health, 2022 Lizano-Barrantes C +8 more
europepmc +1 more source
Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients
The Anatomical Record, EarlyView.Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey +5 more
wiley +1 more source
Is guideline-based education prehospitalization associated with improved inhaler technique in high-risk children? [PDF]
Ann Allergy Asthma Immunol, 2022 Wei H, Press VG, Volerman A.
europepmc +1 more source
Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis
Arthritis &Rheumatology, EarlyView.Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo +7 more
wiley +1 more source
Patient Preference and Adherence, 2016 Pieter Nicolaas Richard Dekhuijzen,1 Federico Lavorini,2 Omar S Usmani3 1Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; 2Department of Experimental and Clinical Medicine, Careggi University Hospital ...
Dekhuijzen PNR, Lavorini F, Usmani OS
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