Results 91 to 100 of about 1,035,048 (296)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Neutronic characteristic analysis of the GAMA microreactor
HeliyonThe GAMA Microreactor is a low-power nuclear power plant dedicated for remote area with a power output of 300 kWe. The primary characteristics of the GAMA Microreactor are its system compactness, design simplicity, and safe operation without moving parts.
Andang Widi Harto +7 more
doaj +1 more source
Chemical Engineering Transactions, 2014 Organizations associated with the handling, processing or storage of hazardous substances, have the potential for major accidents. The offshore industry, for example, handles dangerous substances like crude oil and gas.
P. Okoh, S. Haugen
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Preparing safety data packages for experimenters using the Get Away Special (GAS) carrier system [PDF]
The implementation of NSTS 1700.7B and more forceful scruntiny of data packages by the Johnson Space Flight Center (JSC) lead to the development of a classification policy for GAS/CAP payloads.
Kosko, Jerome
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
LOOKING FOR GOVERNMENT'S ROLE AS AN AGRICULTURAL SAFETY NET [PDF]
What makes agriculture especially deserving of an active government safety net? What is different about agricultural production? Are we concerned about a safe and reliable food supply or about farmers' incomes and returns to assets?
Dorfman, Jeffrey H.
core +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Inadequacy of Nation-Based and VaR-Based Safety Nets in the European Union [PDF]
Considered as a social contract, a financial safety net imposes duties and confers rights on different sectors of the economy. Within a nation, elements of incompleteness inherent in this contract generate principal-agent conflicts that are mitigated by ...
Edward J. Kane
core
Enhancing Covid-19 Decision-Making by Creating an Assurance Case for Simulation Models
, 2020 Simulation models have been informing the COVID-19 policy-making process. These models, therefore, have significant influence on risk of societal harms.
Alexander, Rob +6 more
core