Results 91 to 100 of about 155,753 (276)

New approach based on operational strain modal analysis to identify dynamical properties of the high-speed reciprocating operation mechanism

Journal of Low Frequency Noise, Vibration and Active Control, 2019
A high-speed reciprocating operating mechanism with fast running and frequent stopping produces a certain vibration due to inertia. The inherent vibration of this mechanism becomes a key factor affecting positioning accuracy and time.
Xuchu Jiang, Bin Li, Xinyong Mao, Yili Peng, Songping He   +4 more
doaj   +1 more source

Introduction of plasmid encoding for rare tRNAs reduces amplification bias in phage display biopanning

BioTechniques, 2015
Amplification bias is a major hurdle in phage display protocols because it imparts additional, unintended selection pressure beyond binding to the desired target.
Benjamin J. Umlauf, Michael J. McGuire, Kathlynn C. Brown   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Laser powder bed fusion residual stresses: Measurement agreement, machine parity, and baseplate-driven heat-treatment response of 316L stainless steel

Materials & Design
Residual stresses were quantified in a 316 L stainless steel additive manufacturing benchmark arch to assess part-to-part and machine-to-machine variability and the influence of baseplate during stress-relief heat treatment.
R.C. Laurence, D. Canelo-Yubero, G. Abreu Faria, P. Staron, R. Ramadhan, S. Cabeza, A. Paecklar, T. Pirling, J.M. Martinez, M. Sánchez-Poncela, R. Blanc, E. Baustert, Z. Miao, P.J. Withers, M.J. Roy   +14 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Numerical simulation of DED additive manufacturing : full incremental thermo-mechanical resolution and reduced models of inherent strain type

, 2022
Une simulation thermomécanique par éléments finis est développée pour le procédé de fabrication additive DED (directed energy deposition). La simulation est conduite à l'échelle de la pièce, en modélisant le dépôt progressif de matière et la source d ...
Keumo Tematio, Joël
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Prediction of steel plate deformation due to triangle heating using the inherent strain method [PDF]

, 2005
In a shipyard, line heating and triangle heating are two major processes carried out by skilled workers to form curved plates in various shapes under various heating conditions.
Ko, Dae Eun, Ha, Yun Sok, Kim, Tae Hoon, Jang, Chang Doo, Lamb, Thomas   +4 more
core   +1 more source