Results 71 to 80 of about 155,753 (276)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Estimating and Measuring Methods of Residual Stresses Using Inherent Strain Distribution Described as Functions(Report 1). Expression of Inherent strain in Form of Function and Its Estimation.

QUARTERLY JOURNAL OF THE JAPAN WELDING SOCIETY, 1993
When three dimensional welding residual stresses are measured based on inherent strains using Finite Element Method, too many inherent strain components in elements have to be specified to express their distribution. If these are determined experimentally, measurements of elastic strains must be made for points more than the inherent strain components.
Yukio Ueda, Ning Xu Ma
openaire   +3 more sources

Data-driven distortion compensation for laser powder bed fusion process using Gaussian process regression and inherent strain method

Materials & Design
The repeated melting and solidification cycles in the laser powder bed fusion (L-PBF) process lead to significant thermal gradients, resulting in notable distortion in the as-built part.
Wen Dong, Basil J. Paudel, Hao Deng, Shane Garner, Albert C. To   +4 more
doaj   +1 more source

Predicting Welding Deformation of Exposed Forged-and-welded Gear by the Integrated Computational Approach

Jixie chuandong, 2023
In the current study, a large exposed forged-and-welded gear with a diameter of 7 160 mm is taken as the research object. An integrated computational approach is employed to predict the total welding deformation of the gear during welding process.
Qu Tie, Xin Wen, Luo Wenze, Wang Chongyang, Hu Long, Huang Zhiquan, Deng Dean   +6 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Bending Angle Estimated Based on Inherent Strain Theory during Laser Forming

, 2010
Laser forming process analyzed under thermo-elasto-plastic finite element method can better understand the forming mechanism. However, it is very time consuming. This paper introduced the prediction of the deformation in laser forming based on the theory
Hong Shen, Jing Zhou
core   +1 more source

Analysis for Residual Stress and Deformation of Coated Member Using Inherent Strain Method

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 2003
The characteristics of residual stress and deformation of thermal sprayed plates, that are the most important property from the view point of production technique for preventing the cracking and delaminating of coatings, have not always been made clear.
ITOH, Yoshiyasu, TANAKA, Akira, SAITOH, Kazuhiro, TAKAKU, Reki   +3 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Methods of measuring residual stresses in components [PDF]

, 2012
Residual stresses occur in many manufactured structures and components. Large number of investigations have been carried out to study this phenomenon and its effect on the mechanical characteristics of these components.
Olabi, Abdul-Ghani, M. Dassisti, Rossini, Nicola, Rossini, N. S., Benyounis, K. Y., A.G. Olabi, Dassisti, Michele, K.Y. Benyounis, Benyounis, Khaled, Olabi, A. G., N.S. Rossini   +10 more
core   +1 more source

Development of Thermal Distortion Analysis Method Based on Inherent Strain for TMCP Steels

Journal of the Korean Welding and Joining Society, 2008
As ships become to be larger than ever, the thicker plate and the higher tensile steel plate are used in naval shipyard. Though special chemical composition is needed for high-tensile steels, recent high-tensile steels are made by the TMCP(Thermo-Mechanical control process) skill.
Yun-Sok Ha, Jin-Hyuk Yang, Seok-Hee Won, Myung-Su Yi   +3 more
openaire   +2 more sources