Results 51 to 60 of about 154,412 (250)

Comparison of Measured Residual Stress Distributions in Extra-Thick Butt Welds Joined by One-Pass EGW and Multipass FCAW

Advances in Mechanical Engineering, 2014
This study is to measure the welding residual stress distributions in a 70 mm-thick butt weld by one-pass electron gas welding using both the inherent strain method and neutron diffraction method, respectively.
Jeong-Ung Park, GyuBaek An, Wan Chuck Woo, Jae-hyouk Choi, Ninshu Ma   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Research on the Deformation Prediction Method for the Laser Deposition Manufacturing of Metal Components Based on Feature Partitioning and the Inherent Strain Method

Mathematics
Laser deposition manufacturing (LDM) has drawn unprecedented attention for its advantages in manufacturing large-scale and complex metal components.
Bobo Li, Enze Gao, Jun Yin, Xiaodan Li, Guang Yang, Qi Liu   +5 more
doaj   +1 more source

Development of a Practical Straightening Simulation for Welded Structures Using Inherent Strain Method

KnE Engineering, 2018
Welding is the most widely used assembly method available to industries in the construction of metal structures, ships, and offshore platforms. However, this method always produces a certain amount of distortion that will not only degrade the performance but also increase the building cost of the structure, and it should be straightened.
Hector, Ruiz, Naoki, Osawa, Hidekazu, Murakawa, Hidekazu, Murakawa, Sherif, Rashed, Hector, Ruiz, Naoki, Osawa, Hidekazu, Murakawa, Hidekazu, Murakawa, Sherif, Rashed   +9 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Evaluation of Residual Stress for Plasma Sprayed Member Using Inherent Strain Method

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 2007
Residual stresses and the resulting dimensional changes due to thermal spraying can be a major factor in affecting the performance of fabricated parts and components. In this study, the residual stress and deformation behaviors of square plate due to blasting treatment and thermal spraying was clarified by based on an inherent strain method...
ITOH, Yoshiyasu, SUYAMA, Shoko
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Integrating Temperature History into Inherent Strain Methodology for Improved Distortion Prediction in Laser Powder Bed Fusion

Metals
Powder bed fusion–laser beam (PBF-LB) additive manufacturing enables the production of intricate, lightweight metal components aligned with Industry 4.0 and sustainable principles.
Iñaki Setien, Michele Chiumenti, Maria San Sebastian, Carlos A. Moreira, Manuel A. Caicedo   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Numerical investigation of welding deformation diminution for double shell structure using the layered inherent strain

Nuclear Engineering and Technology
Cyclotron is a key scientific tool and indispensable research platform for conducting cutting-edge research in nuclear equipment development as well as innovative applications of nuclear technology.
Cheng Li, Hua Zhai, Lianwei Zhu, Zhihong Liu, Jianguo Ma, Xiaofeng Zhu, Qiong Liu   +6 more
doaj   +1 more source