Results 51 to 60 of about 167,700 (213)

Numerical investigation of welding deformation diminution for double shell structure using the layered inherent strain

Nuclear Engineering and Technology
Cyclotron is a key scientific tool and indispensable research platform for conducting cutting-edge research in nuclear equipment development as well as innovative applications of nuclear technology.
Cheng Li, Hua Zhai, Lianwei Zhu, Zhihong Liu, Jianguo Ma, Xiaofeng Zhu, Qiong Liu   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Data-driven distortion compensation for laser powder bed fusion process using Gaussian process regression and inherent strain method

Materials & Design
The repeated melting and solidification cycles in the laser powder bed fusion (L-PBF) process lead to significant thermal gradients, resulting in notable distortion in the as-built part.
Wen Dong, Basil J. Paudel, Hao Deng, Shane Garner, Albert C. To   +4 more
doaj   +1 more source

Predicting Welding Deformation of Exposed Forged-and-welded Gear by the Integrated Computational Approach

Jixie chuandong, 2023
In the current study, a large exposed forged-and-welded gear with a diameter of 7 160 mm is taken as the research object. An integrated computational approach is employed to predict the total welding deformation of the gear during welding process.
Qu Tie, Xin Wen, Luo Wenze, Wang Chongyang, Hu Long, Huang Zhiquan, Deng Dean   +6 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Modeling and Simulation of Additively Manufactured Cylindrical Component Using Combined Thermomechanical and Inherent Strain Method with Nelder-Mead Optimization. [PDF]

3D Print Addit Manuf, 2023
Taufek T, Manurung YHP, Adenan MS, Akma S, Choo HL, Louhichi B, Bednardz M, Aziz I.   +7 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A novel algorithm for pipeline displacement and bending strain of in-line inspection based on inertia measurement technology

Advances in Mechanical Engineering, 2018
The in-line inspection tool with Inertial Measurement Unit tool is becoming a routine and important practice for many pipeline companies and is effective for whole-line bending strain measurement.
Shucong Liu, Dezhi Zheng, Tianhao Wang, Mengxi Dai, Rui Li, Qingshan Feng   +5 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source