Results 41 to 50 of about 154,412 (250)
Journal of Materials Research and Technology, 2023 The current study investigates the high-temperature deformation behaviour, and microstructural evolution of the laser powder bed fused, Ti modified Al 2024 alloy.
Saurabh Gairola +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
MetalsPowder Bed Fusion–Laser Beam (PBF-LB) is a leading technique in metal additive manufacturing, yet it continues to face challenges related to residual stresses and distortions. The inherent strain method has emerged as a valuable predictive tool, offering
Iñaki Setien +4 more
doaj +1 more source
Journal of Materials Research and Technology, 2022 In order to ensure the dimensional accuracy during welding assembly, external restraints are often used to control welding-induced distortion. The objective of this study is to investigate the effectiveness of external restraints on the reduction of ...
Wei Liang, Dean Deng
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The Scientific World Journal, 2014 Welding-induced deformation not only negatively affects dimension accuracy but also degrades the performance of product. If welding deformation can be accurately predicted beforehand, the predictions will be helpful for finding effective methods to ...
Wei Liang, Hidekazu Murakawa
doaj +1 more source
Study of wave propagation in discontinuous and heterogeneous media with the dynamic lattice method
Scientific Reports, 2022 The development of a new dynamic lattice element method (dynamicLEM) as well as its application in the simulation of the propagation of body waves in discontinuous and heterogeneous media is the focus of this research paper.
Amir S. Sattari +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source