Results 31 to 40 of about 167,700 (213)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Defining and Optimising High-Fidelity Models for Accurate Inherent Strain Calculation in Laser Powder Bed Fusion

Metals
Powder Bed Fusion–Laser Beam (PBF-LB) is a leading technique in metal additive manufacturing, yet it continues to face challenges related to residual stresses and distortions. The inherent strain method has emerged as a valuable predictive tool, offering
Iñaki Setien, Michele Chiumenti, Maria San Sebastian, Manuel A. Caicedo, Carlos A. Moreira   +4 more
doaj   +1 more source

Numerical Prediction of Welding Distortion Considering Gravity Force on General Ship Grillage Structure by Elastic Finite Element Method Using Inherent Strain

Journal of Marine Science and Engineering, 2020
The accurate numerical prediction of welding deformation is important to improve the structural safety of ships and offshore structures in heavy industries.
Donghan Woo, Mitsuru Kitamura
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Angle-Dependent Inherent Strain in LPBF Overhang Structures: Modeling and Residual Stress Validation

Journal of Manufacturing and Materials Processing
Low-angle overhang structures in laser powder bed fusion (LPBF) experience strongly geometry-dependent thermal conditions because the underlying material progressively changes from consolidated solid to low-conductivity powder, which raises a fundamental
Han Wang, Xiutao Tang, Rui Ma, Shouzhen Zhou, Hao Chang, Chengkun Li, Fang Han, Zhihang Zhang, Chengcheng Wang, Xiaoqing Zhu, Zhibo Dong   +10 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Direct Description of Inherent Strains for Thin-Plate Welding Distortion Modelling

Engineering Proceedings
Numerically efficient and user-friendly modelling of component distortions is the key for enabling numerical design of thin-plate structures accounting for welding distortions. This especially concerns large structures, e.g., bridges or ship panels.
Asle J. Tomstad, Ivan Bunaziv, Magnus Eriksson   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Predicting Welding Distortion in a Panel Structure with Longitudinal Stiffeners Using Inherent Deformations Obtained by Inverse Analysis Method

The Scientific World Journal, 2014
Welding-induced deformation not only negatively affects dimension accuracy but also degrades the performance of product. If welding deformation can be accurately predicted beforehand, the predictions will be helpful for finding effective methods to ...
Wei Liang, Hidekazu Murakawa
doaj   +1 more source