Results 31 to 40 of about 154,412 (250)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Multipath Process-Based Inherent Strain Method for Prediction of Deformation of Hull Plate for Integrated Heating and Mechanical Rolling Forming Process

Journal of Marine Science and Engineering
Integrated heating and mechanical rolling forming (IHMRF) has recently been introduced for manufacturing complex curvature hull plates. It fabricates the target curved plate by sequential loading along the multipath.
Zhenshuai Wei, Yao Zhao, Hua Yuan, Lichun Chang   +3 more
doaj   +1 more source

Thermal distortion analysis method for TMCP steel structures using shell element

International Journal of Naval Architecture and Ocean Engineering, 2009
As ships become larger, thicker and higher tensile steel plate are used in shipyard. Though special chemical compositions are required for high-tensile steels, recently they are made by the TMCP (Thermo-Mechanical control process) methodology.
Yunsok Ha, S.R. Rajesh
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Predictive Modeling and Contour Method Validation of Residual Stresses in Notched PBF-LB/M/Ti6Al4V Components Using the Inherent Strain Method

Applied Sciences
Residual stresses and distortions are critical challenges in laser beam powder bed fusion (PBF-LB) of Ti6Al4V components (PBF-LB/M/Ti6Al4V), impacting structural integrity and dimensional accuracy.
Hassan Ali, César M. A. Vasques, Adélio M. S. Cavadas   +2 more
doaj   +1 more source

Numerical Prediction of Welding Distortion Considering Gravity Force on General Ship Grillage Structure by Elastic Finite Element Method Using Inherent Strain

Journal of Marine Science and Engineering, 2020
The accurate numerical prediction of welding deformation is important to improve the structural safety of ships and offshore structures in heavy industries.
Donghan Woo, Mitsuru Kitamura
doaj   +1 more source

Deformation Prediction of Plate Line Rolling Forming Based on Inherent Strain Method [PDF]

Mathematical Problems in Engineering, 2017
Inherent strain method has been widely used as a forecasting and computing method for welding deformation of large complicated structures and further applied to the research of line heating forming. Mechanical forming is a common ship‐hull plate forming method, for which deformation prediction still depends mainly on elastoplastic finite element method.
Changcheng Hu, Yao Zhao, Guoyuan Tang
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source