Results 61 to 70 of about 155,753 (276)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
, 2022 A thermo-mechanical finite element simulation is developed for additive manufacturing by directed energy deposition (DED). The simulation is conducted at the scale of the part, by modelling the progressive deposition of matter and the energy source.
Keumo Tematio, Joël
core +2 more sources
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Advances in Mechanical Engineering, 2014 This study is to measure the welding residual stress distributions in a 70 mm-thick butt weld by one-pass electron gas welding using both the inherent strain method and neutron diffraction method, respectively.
Jeong-Ung Park +4 more
doaj +1 more source
Evaluation of Residual Stress for Plasma Sprayed Member Using Inherent Strain Method
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 2007 Residual stresses and the resulting dimensional changes due to thermal spraying can be a major factor in affecting the performance of fabricated parts and components. In this study, the residual stress and deformation behaviors of square plate due to blasting treatment and thermal spraying was clarified by based on an inherent strain method...
ITOH, Yoshiyasu, SUYAMA, Shoko
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nuclear Engineering and TechnologyCyclotron is a key scientific tool and indispensable research platform for conducting cutting-edge research in nuclear equipment development as well as innovative applications of nuclear technology.
Cheng Li +6 more
doaj +1 more source