Results 91 to 100 of about 72,058 (269)
PLoS ONE, 2012 Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3'UTR of HBEGF were predicted using miRWalk algorithm and followed by DNA sequencing in 103 ...
Gregory Papagregoriou +9 more
doaj +1 more source
Advanced Science, EarlyView.EasyAmplicon 2 is an updated, user‐friendly, and community‐supported pipeline designed for full‐length amplicon data from long‐read sequencing technologies such as PacBio and Nanopore. It supports multiple platforms (Illumina, PacBio, Nanopore, etc.), integrates tools like DADA2 and Emu, and offers a complete workflow from raw data processing to high ...
Hao Luo +24 more
wiley +1 more source
A linear-time algorithm for reconstructing zero-recombinant haplotype configuration on a pedigree
BMC Bioinformatics, 2012 Background When studying genetic diseases in which genetic variations are passed on to offspring, the ability to distinguish between paternal and maternal alleles is essential. Determining haplotypes from genotype data is called haplotype inference. Most
Lai En-Yu +3 more
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Phylogenetic identification of lateral genetic transfer events
BMC Evolutionary Biology, 2006 Background Lateral genetic transfer can lead to disagreements among phylogenetic trees comprising sequences from the same set of taxa. Where topological discordance is thought to have arisen through genetic transfer events, tree comparisons can be used ...
Hamilton Nicholas, Beiko Robert G
doaj +1 more source
On the evolutionary optimisation of many conflicting objectives [PDF]
, 2003 This inquiry explores the effectiveness of a class of modern evolutionary algorithms, represented by Non-dominated Sorting Genetic Algorithm (NSGA) components, for solving optimisation tasks with many conflicting objectives.
Fleming, P.J., Purshouse, R.C.
core
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Advanced Science, EarlyView.The prevailing neglect of cellular hierarchies in current spatial transcriptomics deconvolution often obscures cellular heterogeneity and impedes the identification of fine‐grained subtypes. To address this issue, HIDF employs a cluster‐tree and dual regularization to systematically model cellular hierarchical structures.
Zhiyi Zou +5 more
wiley +1 more source
Guided-Mutation Genetic Algorithm for Mobile IoT Network Relay
IEEE AccessThe Internet of Things (IoT) is a communication scheme which allows various objects to exchange several types of information, enabling functions such as home automation, production management, healthcare, etc.
Gyupil Kam, Kiseop Chung
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Advanced Science, EarlyView.This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu +8 more
wiley +1 more source
EBioMedicineSummary: Background: Oligogenic inheritance has been suggested as a possible mechanism to explain the broad phenotype observed in individuals with differences of sex development (DSD) harbouring NR5A1/SF-1 variants.
Chrysanthi Kouri +73 more
doaj +1 more source