Results 91 to 100 of about 69,200 (270)

A linear-time algorithm for reconstructing zero-recombinant haplotype configuration on a pedigree

BMC Bioinformatics, 2012
Background When studying genetic diseases in which genetic variations are passed on to offspring, the ability to distinguish between paternal and maternal alleles is essential. Determining haplotypes from genotype data is called haplotype inference. Most
Lai En-Yu, Wang Wei-Bung, Jiang Tao, Wu Kun-Pin   +3 more
doaj   +1 more source

Phylogenetic identification of lateral genetic transfer events

BMC Evolutionary Biology, 2006
Background Lateral genetic transfer can lead to disagreements among phylogenetic trees comprising sequences from the same set of taxa. Where topological discordance is thought to have arisen through genetic transfer events, tree comparisons can be used ...
Hamilton Nicholas, Beiko Robert G
doaj   +1 more source

FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single‐Cell RNA‐Seq Samples

Advanced Science, EarlyView.
FemXpress is a computational tool that leverages X‐linked single nucleotide polymorphisms (SNPs) to group cells by the origin of the inactivated X chromosome in female single‐cell RNA sequencing (scRNA‐Seq) data. It demonstrates strong performance on both simulated and real datasets without requiring parental genomic information, and can also identify ...
Xin Wang, Yingke Ma, Fan Li, Wentao Cui, Tianshi Pan, Siqi Wang, Sinan Ma, Qingtong Shan, Chao Liu, Yukai Wang, Ying Zhang, Yuanchun Zhou, Wei Li, Pengfei Wang, Qi Zhou, Guihai Feng   +15 more
wiley   +1 more source

On the evolutionary optimisation of many conflicting objectives [PDF]

, 2003
This inquiry explores the effectiveness of a class of modern evolutionary algorithms, represented by Non-dominated Sorting Genetic Algorithm (NSGA) components, for solving optimisation tasks with many conflicting objectives.
Fleming, P.J., Purshouse, R.C.
core  

Hierarchical Prediction and Perturbation of Chromatin Organization Reveal How Loop Domains Mediate Higher‐Order Architectures

Advanced Science, EarlyView.
HiCGen introduces a hierarchical deep learning framework to predict genome organization across spatial scales using DNA sequences and genomic features. The model enables cross‐cell‐type predictions and in silico perturbation analysis, revealing correlations between loop domains and higher‐order structures.
Jiachen Wei, Yue Xue, Yi Qin Gao
wiley   +1 more source

Guided-Mutation Genetic Algorithm for Mobile IoT Network Relay

IEEE Access
The Internet of Things (IoT) is a communication scheme which allows various objects to exchange several types of information, enabling functions such as home automation, production management, healthcare, etc.
Gyupil Kam, Kiseop Chung
doaj   +1 more source

Biohybrid Computing with Proteinoids and Algae

Advanced Science, EarlyView.
We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Whole-exome sequencing and digital PCR identified a novel compound heterozygous mutation in the NPHP1 gene in a case of Joubert syndrome and related disorders

BMC Medical Genetics, 2017
Background Joubert syndrome and related disorders (JSRD) is a clinically and genetically heterogeneous condition with autosomal recessive or X-linked inheritance, which share a distinctive neuroradiological hallmark, the so-called molar tooth sign.
Shingo Koyama, Hidenori Sato, Manabu Wada, Toru Kawanami, Mitsuru Emi, Takeo Kato   +5 more
doaj   +1 more source

Born to Fear the Machine? Genetic and Environmental Influences on Negative Attitudes toward AI Agents

Advanced Science, EarlyView.
Why do some people fear or distrust AI agents more than others? This twin study shows that negative attitudes toward AI may partly stem from genetic factors, linking them to traits like victim sensitivity and moral beliefs. These findings show that it is not only nurture but also nature that shapes our views of AI, with implications for future human–AI
Xiaojiayu Tan, Yue He, Yuan Zhou, Xinying Li, Qingwen Ding, Yikai Tang, Yu L. L. Luo, Ruolei Gu   +7 more
wiley   +1 more source

Locations and patterns of meiotic recombination in two-generation pedigrees

BMC Medical Genetics, 2009
Background Meiotic crossovers are the major mechanism by which haplotypes are shuffled to generate genetic diversity. Previously available methods for the genome-wide, high-resolution identification of meiotic crossover sites are limited by the laborious
Roberson Elisha DO, Ting Jason C, Currier Duane G, Pevsner Jonathan   +3 more
doaj   +1 more source