Results 91 to 100 of about 443,633 (293)

Revealing the Presence of a Symbolic Sequence Representing Multiple Nucleotides Based on K-Means Clustering of Oligonucleotides

Molecules, 2019
In biological systems, a few sequence differences diversify the hybridization profile of nucleotides and enable the quantitative control of cellular metabolism in a cooperative manner.
Byoungsang Lee, So Yeon Ahn, Charles Park, James J. Moon, Jung Heon Lee, Dan Luo, Soong Ho Um, Seung Won Shin   +7 more
doaj   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

Advanced Science, EarlyView.
This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen, Zhicong Liu, Qiang Shu, Bin Zhou   +3 more
wiley   +1 more source

A miR-1207-5p binding site polymorphism abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy.

PLoS ONE, 2012
Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3'UTR of HBEGF were predicted using miRWalk algorithm and followed by DNA sequencing in 103 ...
Gregory Papagregoriou, Kamil Erguler, Harsh Dweep, Konstantinos Voskarides, Panayiota Koupepidou, Yiannis Athanasiou, Alkis Pierides, Norbert Gretz, Kyriacos N Felekkis, Constantinos Deltas   +9 more
doaj   +1 more source

Multi‐Dimensional Synergistic Engineering for Boosting Nanozyme Catalysis

Advanced Science, EarlyView.
This review systematically analyzes cutting‐edge strategies for boosting nanozyme catalysis through multi‐dimensional synergistic engineering, containing morphology, electronic structure modulation, external stimulation, and machine learning‐aided design.
Yuechun Li, Zhaowen Cui, Chenxin Ji, Cancan Jia, Wentao Zhang, Jianlong Wang, Yizhong Shen   +6 more
wiley   +1 more source

A linear-time algorithm for reconstructing zero-recombinant haplotype configuration on a pedigree

BMC Bioinformatics, 2012
Background When studying genetic diseases in which genetic variations are passed on to offspring, the ability to distinguish between paternal and maternal alleles is essential. Determining haplotypes from genotype data is called haplotype inference. Most
Lai En-Yu, Wang Wei-Bung, Jiang Tao, Wu Kun-Pin   +3 more
doaj   +1 more source

Phylogenetic identification of lateral genetic transfer events

BMC Evolutionary Biology, 2006
Background Lateral genetic transfer can lead to disagreements among phylogenetic trees comprising sequences from the same set of taxa. Where topological discordance is thought to have arisen through genetic transfer events, tree comparisons can be used ...
Hamilton Nicholas, Beiko Robert G
doaj   +1 more source

Clinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation

Advanced Science, EarlyView.
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng   +9 more
wiley   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Active Learning‐Assisted Exploration of [PO40Mo12]3− for Alzheimer's Therapy Insights

Advanced Science, EarlyView.
Bayesian Optimization coupled with active learning to uncover the interaction mechanism of [PO40Mo12]3− on amyloid‐β peptide. Abstract Alzheimer's disease (AD), involving amyloid‐β (Aβ) aggregation, has potential therapeutic modulators in polyoxometalates (POMs) like [PMo12O40]3−.
Lincan Fang, Ruoxue Peng, Luping Xia, Gui‐lin Zhuang   +3 more
wiley   +1 more source