Results 151 to 160 of about 722,236 (315)

Explainable machine learning in cybersecurity: A survey

International Journal of Intelligent Systems, Volume 37, Issue 12, Page 12305-12334, December 2022., 2022
Abstract Machine learning (ML) techniques are increasingly important in cybersecurity, as they can quickly analyse and identify different types of threats from millions of events. In spite of the increasing number of possible applications of ML, successful adoption of ML models in cybersecurity still highly relies on the explainability of those models ...
Feixue Yan, Sheng Wen, Surya Nepal, Cecile Paris, Yang Xiang   +4 more
wiley   +1 more source

Combining face‐to‐face laboratory sessions and a computer simulation effectively teaches gene editing and DNA sequencing to undergraduate genetics students

Biochemistry and Molecular Biology Education, EarlyView.
Abstract Innovative approaches to teaching genetics are essential for improving student engagement and comprehension in this challenging field. Laboratory‐based instruction enhances engagement with the subject while fostering the development of practical competencies and deepening comprehension of theoretical concepts.
Chris Della Vedova, Gareth Denyer, Maurizio Costabile   +2 more
wiley   +1 more source

The SHARK integral generation and digestion system

Journal of Computational Chemistry, Volume 44, Issue 3, Page 381-396, January 30, 2023., 2023
The BLAS level 3‐driven SHARK integral generation and digestion library is introduced and it is discussed how it leads to greatly simplified workflows and substantial computational speedups. Abstract In this paper, the SHARK integral generation and digestion engine is described.
Frank Neese
wiley   +1 more source

Explicable prioritization of genetic variants by integration of rule-based and machine learning algorithms for diagnosis of rare Mendelian disorders

Human Genomics
Background In the process of finding the causative variant of rare diseases, accurate assessment and prioritization of genetic variants is essential. Previous variant prioritization tools mainly depend on the in-silico prediction of the pathogenicity of ...
Ho Heon Kim, Dong-Wook Kim, Junwoo Woo, Kyoungyeul Lee   +3 more
doaj   +1 more source

IPED2: Inheritance Path based Pedigree Reconstruction Algorithm for Complicated Pedigrees [PDF]

arXiv, 2014
Reconstruction of family trees, or pedigree reconstruction, for a group of individuals is a fundamental problem in genetics. The problem is known to be NP-hard even for datasets known to only contain siblings. Some recent methods have been developed to accurately and efficiently reconstruct pedigrees.
arxiv  

Telomere‐to‐telomere reference genome reveals subgenome divergence and large structural variants in Capsella bursa‐pastoris (Brassicaceae)

Biological Diversity, EarlyView.
This study presents a subgenome‐resolved telomere‐to‐telomere reference genome of Capsella bursa‐pastoris, named Cbp_T2T, constructed using PacBio HiFi reads, Nanopore ultra‐long reads, and Hi‐C data. Notable divergences were observed between its subgenomes, and comparative genomics identified two large inversions within the species.
Xin Liu, Lu Liu, Hai‐Fei Yan, Xue‐Jun Ge, Hui‐Run Huang   +4 more
wiley   +1 more source

Exploring the expanse between theoretical questions and experimental approaches in the modern study of evolvability

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 340, Issue 1, Page 8-17, January 2023., 2023
Experimental tests of theories about evolvability have largely been limited to examining the mechanisms by which genetic variation is produced; namely, mutation, and recombination. However, evolvability theory has a much broader domain, and opportunities abound to test ideas about developmental variability, environmental heterogeneity, and the ...
Jeremy A. Draghi, C. Brandon Ogbunugafor
wiley   +1 more source

Algorithm for Searching the Optimal Regulator Supply Mode in the Process of Manufacturing Polymer Products

Инженерные технологии и системы
Introduction. The high demand for polymer products creates the need for constant mo­dernization of the technological aspects of their production, increasing the efficiency of which is impossible without a model description and solving problems of ...
Eldar N. Miftakhov
doaj   +1 more source

Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases

ChemBioChem, EarlyView.
Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
wiley   +1 more source

Chronic steroid use: An overlooked impact on patients with inflammatory bowel disease

JGH Open, Volume 6, Issue 12, Page 910-914, December 2022., 2022
Steroids have long been used in inducing remission of inflammatory bowel disease (IBD), but there is controversy about whether IBD patients should be on chronic steroids for maintenance therapy. In this retrospective study, we aim to identify the complications of chronic steroid use in patients with IBD.
Kristen L Farraj, James R Pellegrini, Rezwan F Munshi, Jose Russe‐Russe, Aboud Kaliounji, Muhammad S Tiwana, Pranay Srivastava, Krishnayer Subramani   +7 more
wiley   +1 more source