Results 211 to 220 of about 72,058 (269)

Pharmacokinetic Model Selection for Personalized Infliximab Dosing in IBD

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Infliximab, a monoclonal antibody used for immune‐mediated diseases, shows high interpatient pharmacokinetic variability. Prolonged exposure increases the risk of adverse effects and costs, making dose personalization essential to balance safety, efficacy, and cost‐effectiveness. Population pharmacokinetic models support individualized dosing,
Sahira Chaiben, Peggy Gandia, Thibaut Jamme, Nicolas Congy, Didier Concordet   +4 more
wiley   +1 more source

Computational Evidence for Digenic Contribution of <i>AIPL1</i> and <i>BBS2</i> Rare Variants in Inherited Retinal Dystrophy. [PDF]

Int J Mol Sci
Alibrandi S, Scimone C, Abate G, Scalinci SZ, Sidoti A, Donato L.   +5 more
europepmc   +1 more source

A Nonparametric Population Pharmacokinetic Model of Selumetinib in Pediatric Patients Diagnosed With Neurofibromatosis‐I or Plexiform Neurofibromas

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT A twice‐daily administration of oral selumetinib (SLT) in the fasted state is the only approved pharmaceutical option for treating inoperable neurofibromatosis type I (NF‐1) and plexiform neurofibromas (PN). In children, exposure to SLT is highly variable, and fasting presents a substantial burden.
Zoltán Köllő, Janka Kovács, Michael N. Neely, Barna Vásárhelyi, Edit Brückner, Attila J. Szabo, Miklós Garami, Gellért Balázs Karvaly   +7 more
wiley   +1 more source

Genetic Diversity and Population Structure of Sika Deer (<i>Cervus nippon</i>) Inferred by mtDNA and Y-Chromosomal Genes. [PDF]

Animals (Basel)
Wang T, Dong Y, Wang L, Liu H, Su W, Xing X.   +5 more
europepmc   +1 more source

Where numerical weather prediction meets large‐eddy simulations in a convective boundary layer during the FESSTVaL field experiment

Quarterly Journal of the Royal Meteorological Society, EarlyView.
We exploit the Field Experiment on Sub‐mesoscale Spatio‐Temporal Variability in Lindenberg (FESSTVaL) to compare the performance of an NWP model at sub‐km resolutions with a traditional LES model. Focusing on clear‐sky ABL turbulence (June 14), shallow convective clouds and surface radiation (June 27), and deep convective cold pools (June 29), we find ...
Mirjana Sakradzija, Maike Ahlgrimm, Frank Beyrich, Chiel van Heerwaarden, Eileen Päschke, Ulrich Görsdorf, Bastian Kirsch, Juerg Schmidli, Noviana Dewani   +8 more
wiley   +1 more source

Convergent Genetic Architecture in Concurrent Anorectal Malformations and Hypospadias: The <i>ESRRA-STARD8</i> Axis as a Key Regulator of Urogenital Development.

J Indian Assoc Pediatr Surg
Goswami C, Sharma J, Sardar R, Gupta D, Kumar S, Jain V, Dhua AK, Yadav DK, Singh H, Goel P.   +9 more
europepmc   +1 more source

A Hereditary Pulmonary Alveolar Proteinosis Caused by a Novel Hemizygous Variation of the CSF2RA Gene Case Report and Literature Review. [PDF]

Mol Genet Genomic Med
Chen Q, Zhang S, Zhu X, Zhu Y, Chen J, Chen H, Xiao G.   +6 more
europepmc   +1 more source

Data assimilation with extremum Monte Carlo methods

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study presents the extremum Monte Carlo filter as a data assimilation method and, in particular, a variant of the variational approach (three‐ and four‐dimensional variational), where the state estimates are obtained by solving an optimization problem numerically over a space of prediction functions, instead of the state space itself.
Karim Moussa, Siem Jan Koopman
wiley   +1 more source

Compound Heterozygous <i>PNKP</i> Variants Causing Developmental and Epileptic Encephalopathy with Severe Microcephaly: Natural History of Two New Cases and Literature Review. [PDF]

NeuroSci
Ragona F, Messina G, Magri S, Doniselli FM, Freri E, Canafoglia L, Solazzi R, Gellera C, Granata T, DiFrancesco JC, Castellotti B.   +10 more
europepmc   +1 more source

Robust Inference for Intermittently‐Monitored Step‐Stress Tests Under Weibull Lifetime Distributions

Quality and Reliability Engineering International, EarlyView.
ABSTRACT Many modern products exhibit high reliability under normal operating conditions. Conducting life tests under these conditions may result in very few observed failures, insufficient for accurate inferences. Instead, accelerated life tests (ALTs) must be performed.
Narayanaswamy Balakrishnan, María Jaenada, Leandro Pardo   +2 more
wiley   +1 more source