Results 211 to 220 of about 443,633 (293)

Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, life‐threatening thrombotic microangiopathy caused by a severe inherited deficiency of ADAMTS13, a von Willebrand factor (VWF) cleaving enzyme. Inadequate clinical endpoint data often make it challenging to statistically power clinical trials in ultra‐rare diseases ...
Cameron McBride, Jiaolong Jiang, Zhiwei Zhang, John Tolsma, Parth Patwari, Björn Mellgård, Majid Vakilynejad, Indranil Bhattacharya, Andy Z. X. Zhu   +8 more
wiley   +1 more source

Direct Data‐Driven State‐Feedback Control of Linear Parameter‐Varying Systems

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT The framework of linear parameter‐varying (LPV) systems has shown to be a powerful tool for the design of controllers for complex nonlinear systems using linear tools. In this work, we derive novel methods that allow us to synthesize LPV state‐feedback controllers directly from only a single sequence of data and guarantee stability and ...
Chris Verhoek, Roland Tóth, Hossam S. Abbas   +2 more
wiley   +1 more source

MAN2A2-related glycosylation defects in autism and cognitive delay. [PDF]

Sci Rep
Treccarichi S, Vinci M, Cirnigliaro L, Messina A, Palmigiano A, Pettinato F, Musumeci A, Chiavetta V, Saccone S, Sturiale L, Calì F, Barone R.   +11 more
europepmc   +1 more source

Resilience of Circular Supply Chains: Analyzing the Impact of Take‐Back Strategies via Efficient Computation of Post‐Disturbance Equilibrium

Sustainable Development, EarlyView.
ABSTRACT Circular supply chains (CSCs) are designed to be restorative and regenerative, recapturing value from end‐of‐life resources to increase efficiency and extend product lifecycles. Take‐back systems play a crucial role in many CSCs by enabling the recovery and reintegration of waste and by‐products from customers and other supply chains (SCs ...
Francesco Cafforio, SangWoo Park, Ilaria Giannoccaro, Layek Abdel‐Malek   +3 more
wiley   +1 more source

Case Report: Acute Psychiatric Behavioral Disturbance in a Patient with Presenilin 1 Gene Mutation Associated with Familial Alzheimer's Disease. [PDF]

Neurol Ther
Xia Y, Liu X, Cui W, Zhi Q, Sun Y.
europepmc   +1 more source

Ecosystem synergies as drivers of acquisitions

Strategic Management Journal, EarlyView.
Abstract Research Summary We examine how the structure of ecosystems shapes firms’ acquisition choices. We develop a theoretical framework comprising three levels of ecosystem structure – local interdependence, clusters, and centrality – that could drive choices of M&A targets based on expected ecosystem synergies, a previously undocumented acquisition
Natalie Burford, Andrew Shipilov, Nathan Furr   +2 more
wiley   +1 more source

Strengthening the Role of <i>PSMC5</i> as a Potential Gene Associated with Neurodevelopmental Disorders. [PDF]

Int J Mol Sci
Vinci M, Musumeci A, Papa C, Ragalmuto A, Saccone S, Federico C, Greco D, Greco V, Calì F, Treccarichi S.   +9 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Systematic genetic assessment of hearing loss using whole-genome sequencing identifies pathogenic variants. [PDF]

Exp Mol Med
Kim JA, Jang SH, Joo SY, Kim SJ, Choi JY, Jung J, Gee HY.   +6 more
europepmc   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, EarlyView.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source