A hierarchical statistical model for estimating population properties of quantitative genes
BMC Genetics, 2002 Background Earlier methods for detecting major genes responsible for a quantitative trait rely critically upon a well-structured pedigree in which the segregation pattern of genes exactly follow Mendelian inheritance laws.
Samuel S Wu +3 more
doaj +2 more sources
Genetic structure of the polymorphic metrosideros (Myrtaceae) complex in the Hwaiian islands using nuclear microsatellite data. [PDF]
PLoS ONE, 2009 BackgroundFive species of Metrosideros (Myrtaceae) are recognized in the Hawaiian Islands, including the widespread M. polymorpha, and are characterized by a multitude of distinctive, yet overlapping, habit, ecological, and morphological forms.
Danica T Harbaugh +4 more
doaj +1 more source
Lossless fitness inheritance in genetic algorithms for decision trees
, 2006 When genetic algorithms are used to evolve decision trees, key tree quality parameters can be recursively computed and re-used across generations of partially similar decision trees. Simply storing instance indices at leaves is enough for fitness to be piecewise computed in a lossless fashion.
Kalles, Dimitris, Papagelis, Athanassios
openaire +2 more sources
A statistical model for estimating maternal-zygotic interactions and parent-of-origin effects of QTLs for seed development. [PDF]
PLoS ONE, 2008 Proper development of a seed requires coordinated exchanges of signals among the three components that develop side by side in the seed. One of these is the maternal integument that encloses the other two zygotic components, i.e., the diploid embryo and ...
Yanchun Li +10 more
doaj +1 more source
Pharmaceuticals, 2019 Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) that cause the following five ...
Beatriz Cadenas +10 more
doaj +1 more source
Ancestral haplotype reconstruction in endogamous populations using identity-by-descent.
PLoS Computational Biology, 2021 In this work we develop a novel algorithm for reconstructing the genomes of ancestral individuals, given genotype or sequence data from contemporary individuals and an extended pedigree of family relationships.
Kelly Finke +10 more
doaj +1 more source
A Method for Calculating Whole-Genome Sequencing Outcomes from Trio Data
AlgorithmsBackground. Whole-genome sequencing (WGS) enables comprehensive detection of genetic variants but faces limitations in benchmarking due to incomplete reference datasets.
Nikita Koltunov +4 more
doaj +1 more source
THE URGENCY OF GENETIC VERIFICATION OF NON-COMPACTION CARDIOMYOPATHY IN CHILDREN: CLINICAL CASES
Вопросы современной педиатрии, 2018 Background. Non-compaction cardiomyopathy is a group of genetically heterogeneous, poorly studied myocardial diseases with a variety of clinical manifestations (from asymptomatic course to progressive systolic dysfunction with symptoms of chronic heart ...
Nataliya A. Sdvigova +7 more
doaj +1 more source
Joint QTL linkage mapping for multiple-cross mating design sharing one common parent. [PDF]
PLoS ONE, 2011 BackgroundNested association mapping (NAM) is a novel genetic mating design that combines the advantages of linkage analysis and association mapping. This design provides opportunities to study the inheritance of complex traits, but also requires more ...
Huihui Li +4 more
doaj +1 more source
Annals of Hepatology, 2023 Introduction and Objectives: Alpha-1 antitrypsin (AAT) is an acute-phase glycoprotein encoded by the SERPINA1 gene. This allele has a codominant expression and Alpha-1 antitrypsin deficiency (AATD) is caused by the inheritance of two affected alleles ...
Mariela Solano-Vargas +5 more
doaj +1 more source