Results 31 to 40 of about 73,228 (270)

Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. [PDF]

, 2019
The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease.
Aguiar, Assis, Auton, Bijvelds, Blackwell, Bonder, D'Antonio, D'Antonio-Chronowska, DeBoever, Dechecchi, DeGiorgio, Dendrou, Diwakar, Dobin, Eguchi, Ernst, Fehrmann, Freudenberg, Gambino, Gensterblum-Miller, Giambartolomei, González-Galarza, Gough, Graffelman, Guo, Hardy, Harrow, Herrmann, Holoshitz, Huang, Jakubosky, Jakubosky, Jensen, Jia, Kilpinen, Kilpinen, Klein, Kontakioti, Kundaje, Laki, Lam, Lee, Leung, Li, Li, Li, Li, Li, Lyczak, Mahdi, Mall, Matzaraki, Mayba, McNicholas, Miretti, Morison, Munder, Nariai, Norman, Oldstone, Panopoulos, Panousis, Pier, Robinson, Sondo, Stegle, Stoltz, Streeter, Tan, Tomati, Trowsdale, Van der Auwera, Vicente, Wilke, Yin, Zhang, Zheng   +76 more
core   +2 more sources

Machine learning analysis of exome trios to contrast the genomic architecture of autism and schizophrenia

BMC Psychiatry, 2020
Background Machine learning (ML) algorithms and methods offer great tools to analyze large complex genomic datasets. Our goal was to compare the genomic architecture of schizophrenia (SCZ) and autism spectrum disorder (ASD) using ML.
Sameer Sardaar, Bill Qi, Alexandre Dionne-Laporte, Guy. A. Rouleau, Reihaneh Rabbany, Yannis J. Trakadis   +5 more
doaj   +1 more source

Organellar inheritance in the green lineage: insights from Ostreococcus tauri [PDF]

, 2013
Along the green lineage (Chlorophyta and Streptophyta), mitochondria and chloroplast are mainly uniparentally transmitted and their evolution is thus clonal. The mode of organellar inheritance in their ancestor is less certain.
Adam Eyre-Walker, Baur, Birky, Bonen, Boynton, Bruen, Correns, De Clerck, Derelle, Duret, Grimsley, Guindon, Gwenael Piganeau, Hasegawa, Hill, Hill, Houliston, Hua, Huang, Hurst, Hutson, Jancek, Kurtz, Larkin, Lewis, Lewontin, Li, MacAlpine, Marin, Marshall, Maréchal, Maynard Smith, McVean, Miyamura, Muller, Nei, Ness, Olson, Piganeau, Posada, Posada, R Development Core Team, Robbens, Rodríguez-Ezpeleta, Romain Blanc-Mathieu, Sager, Sager, Sager, Simpson, Sophie Sanchez-Ferandin, Städler, Sun, Sung, Swofford, Tamura, Tamura, Tsai   +56 more
core   +1 more source

Evolutionary Algorithms for Query Op-timization in Distributed Database Sys-tems: A review

Advances in Distributed Computing and Artificial Intelligence Journal, 2018
Evolutionary Algorithms are bio-inspired optimization problem-solving approaches that exploit principles of biological evolution. , such as natural selection and genetic inheritance.
Zulfiqar ALI, Hafiza Maria KIRAN, Waseem SHAHZAD   +2 more
doaj   +1 more source

Discovering SNP-disease relationships in genome-wide SNP data using an improved harmony search based on SNP locus and genetic inheritance patterns.

PLoS ONE, 2023
Advances in high-throughput sequencing technologies have made it possible to access millions of measurements from thousands of people. Single nucleotide polymorphisms (SNPs), the most common type of mutation in the human genome, have been shown to play a
Fariba Esmaeili, Zahra Narimani, Mahdi Vasighi   +2 more
doaj   +1 more source

Genetic structure of the polymorphic metrosideros (Myrtaceae) complex in the Hwaiian islands using nuclear microsatellite data. [PDF]

PLoS ONE, 2009
BackgroundFive species of Metrosideros (Myrtaceae) are recognized in the Hawaiian Islands, including the widespread M. polymorpha, and are characterized by a multitude of distinctive, yet overlapping, habit, ecological, and morphological forms.
Danica T Harbaugh, Warren L Wagner, Diana M Percy, Helen F James, Robert C Fleischer   +4 more
doaj   +1 more source

A hierarchical statistical model for estimating population properties of quantitative genes

BMC Genetics, 2002
Background Earlier methods for detecting major genes responsible for a quantitative trait rely critically upon a well-structured pedigree in which the segregation pattern of genes exactly follow Mendelian inheritance laws.
Samuel S Wu, Chang-Xing Ma, Rongling Wu, George Casella   +3 more
doaj   +2 more sources

Chloroplast microsatellites: measures of genetic diversity and the effect of homoplasy [PDF]

, 2005
Chloroplast microsatellites have been widely used in population genetic studies of conifers in recent years. However, their haplotype configurations suggest that they could have high levels of homoplasy, thus limiting the power of these molecular markers.
Doyle JJ, Estoup A, Fowler DP, Goldstein DB, Harding RM, Hudson RR, MacDonald GM, Mantel NA, Morgante M, Muona O, Nei M, Powell W, Provan J, Savolainen O, Shigesada N, Tachida H   +15 more
core   +4 more sources

Generalized Hybrid Evolutionary Algorithm Framework with a Mutation Operator Requiring no Adaptation [PDF]

, 2017
This paper presents a generalized hybrid evolutionary optimization structure that not only combines both nondeterministic and deterministic algorithms on their individual merits and distinct advantages, but also offers behaviors of the three originating ...
Chan, Lipton, Foo, Yong Wee, Goh, Cindy, Li, Lin, Li, Yun   +4 more
core   +1 more source

Inheritance-Based Diversity Measures for Explicit Convergence Control in Evolutionary Algorithms

, 2018
Diversity is an important factor in evolutionary algorithms to prevent premature convergence towards a single local optimum. In order to maintain diversity throughout the process of evolution, various means exist in literature.
Fortin Félix-Antoine, Grefenstette John J, Mahfoud Samir W, Šenkerik Roman   +3 more
core   +1 more source