Results 61 to 70 of about 722,236 (315)

Kernel Density Estimation by Genetic Algorithm [PDF]

arXiv, 2022
This study proposes a data condensation method for multivariate kernel density estimation by genetic algorithm. First, our proposed algorithm generates multiple subsamples of a given size with replacement from the original sample. The subsamples and their constituting data points are regarded as $\it{chromosome}$ and $\it{gene}$, respectively, in the ...
arxiv  

Evolutionary L∞ identification and model reduction for robust control [PDF]

, 2000
An evolutionary approach for modern robust control oriented system identification and model reduction in the frequency domain is proposed. The technique provides both an optimized nominal model and a 'worst-case' additive or multiplicative uncertainty ...
Chiang R. Y., Doyle J. C., Golten J., K C Tan, Li Y., Michalewicz Z., Tan K. C., Y Li   +7 more
core   +1 more source

Joint QTL linkage mapping for multiple-cross mating design sharing one common parent. [PDF]

PLoS ONE, 2011
BackgroundNested association mapping (NAM) is a novel genetic mating design that combines the advantages of linkage analysis and association mapping. This design provides opportunities to study the inheritance of complex traits, but also requires more ...
Huihui Li, Peter Bradbury, Elhan Ersoz, Edward S Buckler, Jiankang Wang   +4 more
doaj   +1 more source

Evolving dynamic multiple-objective optimization problems with objective replacement [PDF]

, 2005
This paper studies the strategies for multi-objective optimization in a dynamic environment. In particular, we focus on problems with objective replacement, where some objectives may be replaced with new objectives during evolution.
Chen, Q, Guan, SU, Mo, W
core  

Human gene copy number spectra analysis in congenital heart malformations [PDF]

, 2012
The clinical significance of copy number variants (CNVs) in congenital heart disease (CHD) continues to be a challenge. Although CNVs including genes can confer disease risk, relationships between gene dosage and phenotype are still being defined.
Bick, David P., Broeckel, Ulrich, Goetsch, Mary A., Harris, Susan, Hidestrand, Mats, Mahnke, Donna K., Mitchell, Michael, Pelech, Andrew N., Simpson, Pippa, Stamm, Karl D., Struble, Craig, Tomita-Mitchell, Aoy, Tuffnell, Maureen E., Tweddell, James S.   +13 more
core   +2 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Sintilimab versus docetaxel as second‐line treatment in advanced or metastatic squamous non‐small‐cell lung cancer: an open‐label, randomized controlled phase 3 trial (ORIENT‐3)

Cancer Communications, Volume 42, Issue 12, Page 1314-1330, December 2022., 2022
Abstract Background Treatment options for Chinese patients with locally advanced or metastatic squamous‐cell non‐small‐cell lung cancer (sqNSCLC) after failure of first‐line chemotherapy are limited. This study (ORIENT‐3) aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second‐line treatment in patients with locally advanced ...
Yuankai Shi, Lin Wu, Xinmin Yu, Puyuan Xing, Yan Wang, Jianying Zhou, Airong Wang, Jianhua Shi, Yi Hu, Ziping Wang, Guangyu An, Yong Fang, Sanyuan Sun, Caicun Zhou, Changli Wang, Feng Ye, Xingya Li, Junye Wang, Mengzhao Wang, Yunpeng Liu, Yanqiu Zhao, Ying Yuan, Jifeng Feng, Zhendong Chen, Jindong Shi, Tao Sun, Gang Wu, Yongqian Shu, Qisen Guo, Yi Zhang, Yong Song, Shucai Zhang, Yuan Chen, Wei Li, Hongrui Niu, Wenwei Hu, Lijun Wang, Jianan Huang, Yang Zhang, Ying Cheng, Zhengdong Wu, Bo Peng, Jiya Sun, Christoph Mancao, Yanqi Wang, Luyao Sun   +45 more
wiley   +1 more source

Statistical Methods For Detecting Genetic Risk Factors of a Disease with Applications to Genome-Wide Association Studies [PDF]

, 2015
This thesis aims to develop various statistical methods for analysing the data derived from genome wide association studies (GWAS). The GWAS often involves genotyping individual human genetic variation, using high-throughput genome-wide single ...
Ali, Fadhaa, Ministry of Higher Education and Scientific Research- Republic of Iraq   +1 more
core  

Linkage to chromosome 11p12 in two Maltese families with a highly penetrant form of osteoporosis [PDF]

, 2007
Osteoporosis is a metabolic bone disease with a strong genetic component. Family-based linkage studies were performed by a number of investigators to try to identify loci that might contain genes responsible for an increased susceptibility to ...
Brincat, Mark P., Galea, Raymond P., Vidal, Christopher, Xuereb-Anastasi, Angela   +3 more
core   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source