Results 81 to 90 of about 443,633 (293)

Optimization of boiler's convection tubes based on Genetic Algorithm

, 2016
Genetic Algorithm (GA) is created by Prof. John Holland from Michigan University, deriving from the Darwin’s theory of evolution, Weizmann’s theory of species selection, and Mendel’s theory of inheritance.
Tianyu Zhang, Qing-feng Zhang, Zhenning Zhao, Liang Cheng, Gaojun Liu   +4 more
semanticscholar   +1 more source

Improving sequence-based genotype calls with linkage disequilibrium and pedigree information

, 2012
Whole and targeted sequencing of human genomes is a promising, increasingly feasible tool for discovering genetic contributions to risk of complex diseases.
Whittemore, Alice S., Zhou, Baiyu
core   +1 more source

Practical Considerations in the Design and Use of Non‐Crystalline Metal–Organic Frameworks

Advanced Materials, EarlyView.
This review explores the emerging field of non‐crystalline MOFs ‐ amorphous, liquid, and glassy forms ‐ highlighting how they differ from traditional crystalline MOFs. It discusses their unique synthesis strategies, fundamental principles, and diverse applications.
Hamidreza Mahdavi, Farnaz Zadehahmadi, Mehran Arzani, Leena Melag, Ashley L. Sutton, Muhammad M. Sadiq, Zongli Xie, Matthew R. Hill, Benny D. Freeman   +8 more
wiley   +1 more source

Multifunctional Bamboo Based Materials Empowered by Multiscale Hierarchical Structures—A Critical Review

Advanced Materials, EarlyView.
This review summarizes the latest progress in transforming renewable bamboo resources into high‐value functional materials. It emphasizes how to leverage bamboo's multiscale hierarchical structures to realize innovative applications in energy, construction, environment, and medicine, providing key insights for developing high‐performance bio‐based ...
Yuxiang Huang, Juan Hu, Yahui Zhang, Yanglun Yu, Daihui Zhang, Qiumei Jing, Muhammad Wakil Shahzad, Saddick Donkor, Chi Chen, Chuan Wei Zhang, Ximin He, Ben Bin Xu, Shengbo Ge, Wenji Yu   +13 more
wiley   +1 more source

Bayesian variable selection in searching for additive and dominant effects in genome-wide data.

PLoS ONE, 2012
Although complex diseases and traits are thought to have multifactorial genetic basis, the common methods in genome-wide association analyses test each variant for association independent of the others.
Tomi Peltola, Pekka Marttinen, Antti Jula, Veikko Salomaa, Markus Perola, Aki Vehtari   +5 more
doaj   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Transcriptome‐Wide Association Uncovers LncRNAs Controlling Seed Weight in Soybean

Advanced Science, EarlyView.
This study employs transcriptome‐wide association studies (TWAS) to identify 201 long non‐coding RNAs (lncRNAs) associated with seed weight. Expression quantitative trait locus (eQTL) analysis reveals dynamic and static regulatory variants controlling lncRNA expression across development.
Xiang Wang, Xinyu Jiang, Xiaobo Yuan, Zhipeng Zhou, Zhenwei Zhao, Longfei Wang, Wu Jiao, Wenxue Ye, Qingxin Song   +8 more
wiley   +1 more source

De Novo Design of Specific Heterotrimeric Collagen‐Like Peptides via Genetic Algorithm

Advanced Science, EarlyView.
GRACE is a computational algorithm producing peptide sequences that will reliably fold into composition and registration‐controlled collagen‐like triple helices with user‐specified thermal stability. Additionally, GRACE allows users to specify the inclusion of biologically relevant (or other) sequences to automatically create tailored triple helices ...
Thi H. Bui, Oluwakamisi Adetunji, Carson C. Cole, Le Tracy Yu, Caroline M. Peterson, Jeffrey D. Hartgerink   +5 more
wiley   +1 more source

The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset

Advanced Science, EarlyView.
The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Shuqin Zeng, Hua Wang, Li Zhang, Shiping Li, Yuan Yuan, Mengting Tian, Yi Qu, Junjie Ying, Meicen Zhou, Yong Hu, Jinglan Huang, Rong Zou, Fengyan Zhao, Xiaojuan Su, Qian Liu, Yan He, Jinxing Feng, Weimin Huang, Ying Luo, Zhemin Zhou, Wei Shen, Dezhi Mu, Shaopu Wang   +22 more
wiley   +1 more source