Results 81 to 90 of about 23,923 (239)

‘Where are the adults?’: Troubling child‐activism and children's political participation

British Educational Research Journal, EarlyView.
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley   +1 more source

Fitness inheritance in genetic algorithms [PDF]

, 1995
Robert E. Smith, B. A. Dike, S. A. Stegmann   +2 more
openalex   +1 more source

Intergenerational Enlargement of Human Organs as a Driver of Increased Cancer Risk?

BioEssays, EarlyView.
Identifying the environmental factors and associated mechanisms driving increased cancer incidence in younger generations is a matter of great urgency. Here, we propose and discuss a new potential mechanism: larger organ sizes in younger individuals resulting from intergenerational differences in lifestyle, diet, and environmental exposures.
Costas Koufaris, Vicky Nicolaidou
wiley   +1 more source

A Mathematical Model for Determining Probabilistic Design Space in Mesenchymal Stem Cell Passage Culture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT With their many therapeutic functions, mesenchymal stem cells (MSCs) are promising sources for regenerative medicine. However, in the manufacture of MSCs, without a method for exploring the effects of long‐term passage on cell proliferation potentials, the design of passage culture processes is challenging.
Keita Hirono, Yusuke Hayashi, Yuuki Ogawa, Masahiro Kino‐oka, Hirokazu Sugiyama   +4 more
wiley   +1 more source

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

Clinical Pharmacology &Therapeutics, EarlyView.
The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6‐mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes
Inger Johansson, Emmanouella M. Xanthopoulou, Yitian Zhou, Anabel Sanchez‐Spitman, Maaike van der Lee, Birgit M. Wollmann, Elisabet Størset, Jesse J. Swen, Henk‐Jan Guchelaar, Espen Molden, Marin M. Jukic, Magnus Ingelman‐Sundberg   +11 more
wiley   +1 more source

Explicable prioritization of genetic variants by integration of rule-based and machine learning algorithms for diagnosis of rare Mendelian disorders

Human Genomics
Background In the process of finding the causative variant of rare diseases, accurate assessment and prioritization of genetic variants is essential. Previous variant prioritization tools mainly depend on the in-silico prediction of the pathogenicity of ...
Ho Heon Kim, Dong-Wook Kim, Junwoo Woo, Kyoungyeul Lee   +3 more
doaj   +1 more source

A review of multiscale numerical modeling of rock mechanics and rock engineering

Deep Underground Science and Engineering, EarlyView.
Multiscale numerical methods of rock mechanics and rock engineering are reviewed, and the review results show that more attention should be paid to the development of an advanced constitutive model in addition to numerical techniques themselves. Abstract Rock is geometrically and mechanically multiscale in nature, and the traditional phenomenological ...
Xindong Wei, Zhe Li, Gaofeng Zhao
wiley   +1 more source

Lossless fitness inheritance in genetic algorithms for decision trees

, 2006
Dimitris Kalles, Athanassios Papagelis
openalex   +3 more sources

Slit tube responses and rock fracture characteristics in slit charge blasting under high in situ stress

Deep Underground Science and Engineering, EarlyView.
In this article, the finite element method‐smoothed particle hydrodynamics adaptive coupling algorithm is applied to numerically simulate and analyze the dynamic response of the slit tube and the crack propagation under high in situ stress. The dynamic response of the slit tube mainly exhibits radial response in the vertical direction of the slit and ...
Zhe Sui, Liyun Yang, Lijun Wu, Chenxi Ding   +3 more
wiley   +1 more source

Algorithm for Searching the Optimal Regulator Supply Mode in the Process of Manufacturing Polymer Products

Инженерные технологии и системы
Introduction. The high demand for polymer products creates the need for constant mo­dernization of the technological aspects of their production, increasing the efficiency of which is impossible without a model description and solving problems of ...
Eldar N. Miftakhov
doaj   +1 more source