Results 81 to 90 of about 722,236 (315)

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

How to shift bias: Lessons from the Baldwin effect [PDF]

, 1996
An inductive learning algorithm takes a set of data as input and generates a hypothesis as output. A set of data is typically consistent with an infinite number of hypotheses; therefore, there must be factors other than the data that determine the output
Turney, Peter D.
core   +2 more sources

FAIR and Structured Data: A Domain Ontology Aligned with Standard‐Compliant Tensile Testing

Advanced Engineering Materials, EarlyView.
The digitalization in materials science and engineering is discussed, emphasizing the importance of digital workflows and ontologies in managing diverse experimental data. Challenges such as quality assurance and data interoperability are tackled with semantic web technologies, focusing and introducing the tensile test ontology (TTO).
Markus Schilling, Bernd Bayerlein, Philipp von Hartrott, Jörg Waitelonis, Henk Birkholz, Pedro Dolabella Portella, Birgit Skrotzki   +6 more
wiley   +1 more source

Parameter Estimation and Quantitative Parametric Linkage Analysis with GENEHUNTER-QMOD [PDF]

, 2012
Objective: We present a parametric method for linkage analysis of quantitative phenotypes. The method provides a test for linkage as well as an estimate of different phenotype parameters.
Abecasis GR, Almasy L, Birgin EG, Birgin EG, Chen WM, Dietter J, Dietter J, Dudbridge F, Elston RC, Franke D, Gudbjartsson DF, Haseman JK, Holmans P, Kleensang A, Knapp M, Kong A, Konstantin Strauch, Kruglyak L, Kurz T, Kurz T, Lander ES, Lathrop GM, Mattheisen M, Morris N, Pratt SC, Strauch K, Strauch K, Thomas Künzel, Ziegler A   +28 more
core   +1 more source

An Ontology‐Augmented Digital Twin for Fiber‐Reinforced Polymer Structures at the Example of Wind Turbine Rotor Blades

Advanced Engineering Materials, EarlyView.
A methodology for establishing an ontology‐augmented structural digital twin for fiber‐reinforced polymer structures dedicated to individual lifetime prediction, in this case, a wind turbine rotor blade, is introduced. The methodology resembles the manufacturing as well as the operation of the structure.
Marc Luger, Alexander Seidel, Ursula Pähler, Sebastian Schröck, Peter Hofmann, Sebastian Kölbl, Klaus Drechsler   +6 more
wiley   +1 more source

Myths and Legends of the Baldwin Effect [PDF]

, 1996
This position paper argues that the Baldwin effect is widely misunderstood by the evolutionary computation community. The misunderstandings appear to fall into two general categories.
Turney, Peter
core   +3 more sources

Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. [PDF]

, 2019
The MHC region is highly associated with autoimmune and infectious diseases. Here we conduct an in-depth interrogation of associations between genetic variation, gene expression and disease.
Aguiar, Assis, Auton, Bijvelds, Blackwell, Bonder, D'Antonio, D'Antonio-Chronowska, DeBoever, Dechecchi, DeGiorgio, Dendrou, Diwakar, Dobin, Eguchi, Ernst, Fehrmann, Freudenberg, Gambino, Gensterblum-Miller, Giambartolomei, González-Galarza, Gough, Graffelman, Guo, Hardy, Harrow, Herrmann, Holoshitz, Huang, Jakubosky, Jakubosky, Jensen, Jia, Kilpinen, Kilpinen, Klein, Kontakioti, Kundaje, Laki, Lam, Lee, Leung, Li, Li, Li, Li, Li, Lyczak, Mahdi, Mall, Matzaraki, Mayba, McNicholas, Miretti, Morison, Munder, Nariai, Norman, Oldstone, Panopoulos, Panousis, Pier, Robinson, Sondo, Stegle, Stoltz, Streeter, Tan, Tomati, Trowsdale, Van der Auwera, Vicente, Wilke, Yin, Zhang, Zheng   +76 more
core   +2 more sources

A Workflow‐Centric Approach to Generating FAIR Data Objects for Computationally Generated Microstructure‐Sensitive Mechanical Data

Advanced Engineering Materials, EarlyView.
A novel metadata schema is introduced to address the sparsity of microstructure‐sensitive mechanical data. The design follows the material modeling workflow, as each run results in the definition of unique data objects. The schema includes categorical elements to ensure findability, accessibility, interoperability, and reusability (FAIR). This approach
Ronak Shoghi, Alexander Hartmaier
wiley   +1 more source

Clinical manifestations of familial exudative vitreoretinopathy in children with nucleotide sequence alterations in the FZD4 gene

Российский офтальмологический журнал, 2022
Familial exudative vitreoretinopathy (FEVR)is a rare genetically heterogeneous disease with multiple types of inheritance (autosomal dominant, autosomal recessive, X-linked) and widely varying clinical features. Up to 40 % of cases of FEVR are associated
L. A. Katargina, V. V. Kadyshev, E. V. Denisova, E. A. Geraskina, A. V. Marakhonov, S. A. Garifullina, I. V. Zolnikova, R. A. Zinchenko   +7 more
doaj   +1 more source

Non-genetic inheritance restraint of cell-to-cell variation [PDF]

, 2020
Heterogeneity in physical and functional characteristics of cells (e.g. size, cycle time, growth rate, protein concentration) proliferates within an isogenic population due to stochasticity in intracellular biochemical processes and in the distribution of resources during divisions.
arxiv   +1 more source