Results 181 to 190 of about 251,009 (263)

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, EarlyView.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Serendipitous Symptom Control: Allopurinol for Spasticity in a Case of SPG4-Linked Hereditary Spastic Paraplegia-A Case Report. [PDF]

Clin Case Rep
Elmezayen ZW, Salameh H, Afana A, Zahran A.   +3 more
europepmc   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source

The Advanced Confidentiality Engine as a Scalable Tool for the Pseudonymization of Biomedical Data in Translational Settings: Development and Usability Study.

J Med Internet Res
Müller A, Wündisch E, Wirth FN, Meier Zu Ummeln S, Weber J, Prasser F.   +5 more
europepmc   +1 more source

Aspartame and cardiovascular disease: Unraveling potential molecular mechanisms through integrative network toxicology, molecular docking, and dynamics simulation. [PDF]

Medicine (Baltimore)
Yang T, Luo J, Zhang L, Li H, Wang J.
europepmc   +1 more source

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source

Spatial self-organization of cancer stem cell niches revealed by live single-cell imaging. [PDF]

Stem Cell Res Ther
Brulé M, Horochowska A, Fontaine E, Torero-Ibad R, Woesteland F, Denoulet M, Pesez J, Adriaenssens E, Toillon RA, Le Bourhis X, Pfeuty B, Lagadec C, Anquez F.   +12 more
europepmc   +1 more source

3D‐Printed Aerogel Metamaterials with Multiple Heterogeneous Interfaces Enables Integrated Control of Microwave Field, Acoustic Field, and Thermal Field

Advanced Science, EarlyView.
The Direct‐Ink‐Writing (DIW) 3D‐printed aramid nanofibers (ANF)/carbon nanotubes (CNT)/liquid metal (LM) aerogel metamaterial demonstrates an effective and lightweight strategy to achieve polarization insensitive & ultra‐wideband microwave absorption from 2.65‐18 GHz, broadband noise reduction effect in the 2800‐6400 Hz and thermal suppression ...
Yijie Liu, Kokila Khanal, Weimeng Chu, Sreekanth Ginnaram, Yijing Zhao, Chunlin Jia, Udeshwari Jamwal, Jiaqi Tao, Lvtong Duan, Wentao Yan, Yong Yang   +10 more
wiley   +1 more source

Evolutionary features in a minimal physical system: Diversity, selection, growth, inheritance, and adaptation. [PDF]

Proc Natl Acad Sci U S A
Bunin G, Rivoire O.
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source