Results 81 to 90 of about 309,203 (310)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Upper limb peripheral neuropathy in sickle cell anemia: MR neurography appearances

Indian Journal of Radiology and Imaging, 2019
Sickle cell anemia is an inherited disorder with many systemic complications. Peripheral neuropathy related to this disorder has been sparsely reported.
Feng Poh, Rocco Hlis, Avneesh Chhabra
doaj   +1 more source

Border Terriers under primary veterinary care in England: demography and disorders [PDF]

, 2017
The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers receiving veterinary care in England using de ...
A Agresti, A Egenvall, A Gough, A Tvarijonaviciute, A-S Lequarré, AJ German, AR Boyko, BA Niemiec, BR Kirkwood, C Dedola, C Gorrel, D O'Neill, DD Sleator, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, EM Lund, EM Lund, ER Shore, F Mariani, FC Calboli, FE Taylor-Brown, FS Roedler, GJ Patronek, HF Proschowsky, HG Parker, HG Parker, ID Robertson, J Lipton, J Sampson, J Stavisky, J Summers, JF Summers, K Christensen, L Asher, L Kearsley-Fleet, LJ DeBowes, LM Collins, LM Collins, LT Glickman, LT Glickman, M Demirkiran, M Downes, M Ratsitorahina, MD Willard, MJ Mattin, OV Horst, P Bateson, P D’Aquila, P Sandøe, PC Bartlett, PD McGreevy, PE Holt, R Collins, R Johns, RA Packer, RK Wayne, S Acharya, T Lewis, V Black, VJ Adams, W Low   +66 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Eye involvement in inherited metabolic disorders

Therapeutic Advances in Ophthalmology, 2020
Inherited metabolic disorders are a large group of rare disorders affecting normal biochemical pathways. Many metabolic disorders can present with symptoms affecting the eye, and eye disorders can evolve later in the natural history of an already ...
James E. Davison
doaj   +1 more source

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Epidemiological associations between brachycephaly and upper respiratory tract disorders in dogs attending veterinary practices in England [PDF]

, 2015
Background: Brachycephalic dog breeds are increasingly common. Canine brachycephaly has been associated with upper respiratory tract (URT) disorders but reliable prevalence data remain lacking.
AG Drake, AJ German, AK Hussein, Anon, BR Kirkwood, C Rusbridge, CD Knecht, CV Torrez, D Alderton, D Aron, D Bannasch, D Georgevsky, D Lorenzi De, DA Koch, DG O’Neill, DG O’Neill, DG O’Neill, DN Irion, EM Lund, F Bernaerts, FJ Fasanella, FS Roedler, HG Parker, I Dohoo, J Clutton-Brock, J Sampson, JJ Schoenebeck, JJ Schoenebeck, K Lindblad-Toh, L Asher, LM Collins, MJ Schmidt, MW Neff, NJ Beausoleil, P Bateson, PD McGreevy, RMA Packer, S Fonfara, S Isono, T Emmerson   +39 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Generation of induced pluripotent stem cell line (MIPTi002-A) derived from a patient with a heterozygous type mutation in the CDC73 gene

Stem Cell Research
CDC73-related disorders are inherited in an autosomal dominant manner. An individual with a CDC73-related disorder may have inherited the disorder from an affected parent or developed it as the result of a de novo pathogenic variant of CDC73.
Almaqdad Alsalloum, Walaa Asaad, Julia Krupinova, Evgenii Kegeles, Polina Sirotkina, Alexandra Panova, Olga Mityaeva, Pavel Volchkov   +7 more
doaj   +1 more source

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

, 2020
Arterial tortuosity syndrome (ATS) is a recessively inherited connective tissue disorder, mainly characterized by tortuosity and aneurysm formation of the major arteries.
Barnhoorn, Sander, Beyens, Aude, Boel, Annekatrien, Burger, Joyce, Callewaert, Bert, Casteleyn, Christophe, Coucke, Paul, Descamps, Benedicte, Essers, Jeroen, Reinhardt, Dieter, Renard, Marjolijn, van der Pluijm, Ingrid, Vanhomwegen, Marine, Vanhove, Christian, Willaert, Andy   +14 more
core   +1 more source