Results 31 to 40 of about 5,172,195 (247)

Reduced Electroretinogram Responses in Morphologically Normal Retina in Patients with Primary Hyperoxaluria Type 1

Ophthalmology Science, 2023
Purpose: To describe ocular findings in individuals with primary hyperoxaluria type 1 (PH1), focusing on the correlations between retinal anatomy and retinal function.
Efrat Naaman, MD, Netta Malul, MD, Shadi Safuri, MD, PhD, Nitai Bar, MD, Shirley Pollack, MD, Daniella Magen, MD, Rina Leibu, MD, Ido Perlman, PhD, Shiri Zayit-Soudry, MD   +8 more
doaj   +1 more source

Retinal arterioles narrow with increasing duration of anti-retroviral therapy in HIV infection: a novel estimator of vascular risk in HIV? [PDF]

, 2012
OBJECTIVES: HIV infection is associated with an increased risk of age-related morbidity mediated by immune dysfunction, atherosclerosis and inflammation.
Pathai, Sophia, Peto, Tunde; id_orcid, Tien Y Wong, Weiss, Helen A, Helen A Weiss, Colin Cook, Cook Colin, Tien Y. Wong, Tunde Peto, Lawn, Stephen D, Gilbert Clare E., Weiss Helen A., Wong Tien Y., Stephen D Lawn, Leris M D'Costa, Clare E. Gilbert, Peto Tunde, Sophia Pathai, Pathai Sophia, Leris M. D’costa, Lawn Stephen D., Cook, Colin, Helen A. Weiss, D’Costa Leris M., Gilbert, Clare E, Stephen D. Lawn, Peto, Tunde, Wong, Tien Y, D'Costa, Leris M, Clare E Gilbert   +29 more
core   +1 more source

Real-World Comparison of Overall Survival Among Patients With and Without Inherited Retinal Diseases

Vision
This study compared real-world overall survival and the risk of physical comorbidities and mental health conditions among patients aged
Byron L. Lam, Carlos E. Mendoza-Santiesteban, Dominic Pilon, Dejan Milentijevic, Laura Morrison, Samuel Schwartzbein, Claire Vanden Eynde, Marie-Hélène Lafeuille, Patrick Lefebvre, Ninel Z. Gregori   +9 more
doaj   +1 more source

A cross-sectional study to assess the clinical utility of modern visual function assessments in patients with inherited retinal disease: a mixed methods observational study protocol

BMC Ophthalmology, 2023
Background Treatment options for patients with inherited retinal disease are limited, although research into novel therapies is underway. To ensure the success of future clinical trials, appropriate visual function outcome measures that can assess ...
Laura J. Taylor, Amandeep S. Josan, Irene Stratton, Jasleen K. Jolly, Robert E. MacLaren   +4 more
doaj   +1 more source

Early stages of retinal development depend on Sec13 function [PDF]

, 2013
ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Feng, Yi, Schmidt, Katy, Stephens, David J, Yi Feng, Katy Schmidt, David J. Stephens, Florencia Cavodeassi, Cavodeassi, Florencia   +7 more
core   +1 more source

Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]

, 2015
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB, Pearson, RA, Hippert, C, Barber, AC, West, EL, Smith, AJ, Ali, RR   +6 more
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pearls and Pitfalls of Adaptive Optics Ophthalmoscopy in Inherited Retinal Diseases

Diagnostics, 2023
Adaptive optics (AO) retinal imaging enables individual photoreceptors to be visualized in the clinical setting. AO imaging can be a powerful clinical tool for detecting photoreceptor degeneration at a cellular level that might be overlooked through ...
Helia Ashourizadeh, Maryam Fakhri, Kiana Hassanpour, Ali Masoudi, Sattar Jalali, Danial Roshandel, Fred K. Chen   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source