Results 1 to 10 of about 20,424 (114)

Targeting molecular pathways for the treatment of inherited retinal degeneration [PDF]

Neural Regeneration Research, 2020
Inherited retinal degeneration is a major cause of incurable blindness characterized by loss of retinal photoreceptor cells. Inherited retinal degeneration is characterized by high genetic and phenotypic heterogeneity with several genes mutated in ...
Meltem Kutluer, Li Huang, Valeria Marigo
doaj   +2 more sources

A spontaneous nonhuman primate model of inherited retinal degeneration [PDF]

JCI Insight
Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness. Hereditary macular diseases, in particular, are significant in their effect on the specialized, central cone photoreceptor–rich macula responsible for ...
Wei Yi, Mingming Xu, Ying Xue, Yingxue Cao, Ziqi Yang, Lingli Zhou, Yang Zhou, Le Shi, Xiaomei Mai, Zehui Sun, Wenjie Qing, Yuying Li, Aolun Qing, Kaiwen Zhang, Lechun Ou, Shoudeng Chen, Elia J. Duh, Xialin Liu   +17 more
doaj   +2 more sources

Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration [PDF]

Experimental Eye Research, 2021
Nathanael Matei, Mahnaz Shahidi, Norman Blair   +2 more
exaly   +2 more sources

Drug Discovery Strategies for Inherited Retinal Degenerations

Biology, 2022
Inherited retinal degeneration is a group of blinding disorders afflicting more than 1 in 4000 worldwide. These disorders frequently cause the death of photoreceptor cells or retinal ganglion cells.
Arupratan Das, Yoshikazu Imanishi
doaj   +1 more source

Neural and Müller glial adaptation of the retina to photoreceptor degeneration

Neural Regeneration Research, 2023
The majority of inherited retinal degenerative diseases and dry age-related macular degeneration are characterized by decay of the outer retina and photoreceptors, which leads to progressive loss of vision.
Henri O Leinonen, Edward Bull, Zhongjie Fu   +2 more
doaj   +1 more source

Twelve-month Natural History Study of Centrosomal Protein 290 (CEP290)-associated Inherited Retinal Degeneration [PDF]

Ophthalmology Science
Byron Lam, Carel B Hoyng, Eric A Pierce
exaly   +2 more sources

Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice

iScience, 2023
Summary: Photoreception requires amplification by mammalian rhodopsin through G protein activation, which requires a visual cycle. To achieve this in retinal gene therapy, we incorporated human rhodopsin cytoplasmic loops into Gloeobacter rhodopsin ...
Yusaku Katada, Kazuho Yoshida, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Hideki Kandori, Kazuo Tsubota, Toshihide Kurihara   +9 more
doaj   +1 more source

Oxidative Stress as a Main Contributor of Retinal Degenerative Diseases

Antioxidants, 2022
Retinal degenerative diseases, including inherited retinal dystrophies (IRDs) and acquired multifactorial diseases, such as age-related macular degeneration (AMD), diabetic retinopathy (DR) or ganglion cell damage secondary to glaucoma or other ...
Isabel Pinilla, Victoria Maneu
doaj   +1 more source

Retinal Proteome Profiling of Inherited Retinal Degeneration Across Three Different Mouse Models Suggests Common Drug Targets in Retinitis Pigmentosa [PDF]

Molecular and Cellular Proteomics
Henri Leinonen, Krzysztof Palczewski, Daniel Figeys   +2 more
exaly   +2 more sources

A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases

Frontiers in Transplantation, 2023
Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa.
Davinia Beaver, Ioannis Jason Limnios
doaj   +1 more source