Results 1 to 10 of about 125,005 (308)
Oxysterols and retinal degeneration [PDF]
British Journal of Pharmacology, 2021 Retinal degeneration, characterised by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate cholesterol ...
Reem Hasaballah Alhasani +2 more
exaly +7 more sources
HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration
Redox Biology, 2021 Oxidative stress-mediated retinal pigment epithelium (RPE) degeneration plays a vital role in retinal degeneration with irreversible visual impairment, most notably in age-related macular degeneration (AMD), but a key pathogenic factor and the targeted ...
Zhimin Tang, Yahan Ju, Xiaochan Dai
exaly +3 more sources
Microglial phagocytosis of bipolar cells triggers inner retinal degeneration in Rs1-KO mice [PDF]
Cell Communication and SignalingBackground X-linked juvenile retinoschisis (XLRS) is a hereditary retinal disorder caused by mutations in the RS1 gene that leads to the formation of cavities in the inner nuclear layer (INL) and progressive vision loss, characterized by a ...
Jin Young Yang +10 more
doaj +2 more sources
Topical eye treatment with JGRi1, a protein/protein interaction inhibitor, mitigates retinal degeneration [PDF]
Cell Death and DiseaseRetinal diseases (RDs) involve the degeneration of retinal cells, particularly retinal ganglion cells (RGCs), often driven by glutamate imbalance and aberrant signaling.
Marco Cimino +7 more
doaj +2 more sources
Stem Cell Reports, 2018 Summary: Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies.
Hung-Ya Tu +2 more
exaly +3 more sources
Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes [PDF]
, 2016 PurposeLoss of photoreceptor cells is associated with retinal vascular degeneration in retinitis pigmentosa, whereas the presence of photoreceptor cells is implicated in vascular degeneration in diabetic retinopathy.
Aicha Saâdane, Krzysztof Palczewski
exaly +2 more sources
Cell Death Discovery, 2022 Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and temporal differentiation of retinal cell types.
Si Hyung Lee +12 more
doaj +1 more source
Whole-exome sequencing in 168 Korean patients with inherited retinal degeneration
BMC Medical Genomics, 2021 Background To date, no genetic analysis of inherited retinal disease (IRD) using whole-exome sequencing (WES) has been conducted in a large-scale Korean cohort.
Dae Joong Ma +8 more
doaj +1 more source
Lentiviral Vectors for Ocular Gene Therapy
Pharmaceutics, 2022 This review offers the basics of lentiviral vector technologies, their advantages and pitfalls, and an overview of their use in the field of ophthalmology.
Yvan Arsenijevic +3 more
doaj +1 more source
Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage
Frontiers in Neuroscience, 2022 Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration.
Shaojun Wang +4 more
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