Neural Reprogramming in Retinal Degeneration [PDF]
Investigative Opthalmology & Visual Science, 2007 Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration.Excitation mapping with organic ...
Marc, Robert E +7 more
openaire +2 more sources
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration
Cell Reports, 2020 Summary: Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction.
Kelly Mulfaul +13 more
doaj +1 more source
Preliminary study on electrophysiological changes after cellular autograft in age-related macular degeneration [PDF]
, 2014 Background: Evolving atrophic macular degeneration represents at least 80% of all macular degenerations and is currently without a standardized care. Autologous fat transplantation (AFT) efficacy was demonstrated by several studies, since these cells are
C., Limoli +4 more
core +1 more source
Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]
, 2015 Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Ali, RR +6 more
core +1 more source
Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong +5 more
core +2 more sources
Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. [PDF]
, 2019 As a part of the central nervous system, the retina may reflect both physiologic processes and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put forth to understand how Alzheimer's disease (AD) pathology may manifest
Honma, Patrick +2 more
core +1 more source
CellsThree-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines to allow in vitro studies on retinal progenitors and photoreceptors and their developmental dynamics
Oleksandr Zabiegalov +10 more
doaj +1 more source
Optical Coherence Tomographic Angiography Imaging in Age-Related Macular Degeneration. [PDF]
, 2017 Optical coherence tomographic angiography (OCTA) is emerging as a rapid, noninvasive imaging modality that can provide detailed structural and flow information on retinal and choroidal vasculature.
Desai, Ria +5 more
core +3 more sources
Genetic and clinical characteristics of PROM1-related retinal degeneration in Korean
Scientific Reports, 2023 This scientific report aims to comprehensively describe the genetic and clinical characteristics of PROM1-related retinal degeneration in Korean patients.
Sungsoon Hwang +3 more
doaj +1 more source
Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. [PDF]
, 2019 Neuroinflammation commonly accompanies neurodegeneration, but the specific roles of resident and infiltrating immune cells during degeneration remains controversial.
Burns, Marie E +3 more
core +2 more sources