Results 1 to 10 of about 73,477 (262)
A single Musashi gene allele is sufficient to maintain mouse photoreceptor cells. [PDF]
PLoS ONEIn vertebrates, two genes, Musashi1 (Msi1) and Musashi2 (Msi2), encode for highly similar Musashi protein paralogs. The Musashi proteins are known to bind to 3'-UTRs and control translation.
Bohye Jeong, Peter Stoilov
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Deletion of prominin-1 in mice results in disrupted photoreceptor outer segment protein homeostasis [PDF]
International Journal of Ophthalmology, 2021 AIM: To illustrate the underlying mechanism how prominin-1 (also known as Prom1) mutation contribute to progressive photoreceptor degeneration. METHODS: A CRISPR-mediated Prom1 knockout (Prom1-KO) mice model in the C57BL/6 was generated and the ...
Yu-Shu Xiao +12 more
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The Usher syndrome 1C protein harmonin regulates canonical Wnt signaling
Frontiers in Cell and Developmental Biology, 2023 Human Usher syndrome (USH) is the most common form of hereditary combined deaf-blindness. USH is a complex genetic disorder, and the pathomechanisms underlying the disease are far from being understood, especially in the eye and retina.
Jessica Schäfer +8 more
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Journal of Translational Medicine, 2023 Background Photoreceptor degeneration underpinned by oxidative stress-mediated mitochondrial dysfunction and cell death leads to progressive and irreversible vision impairment. Drug treatments that protect against photoreceptor degeneration are currently
Daijin Li +9 more
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Cells, 2020 Photoreceptor disease results in irreparable vision loss and blindness, which has a dramatic impact on quality of life. Pathogenic mutations in RP1L1 lead to photoreceptor degenerations such as occult macular dystrophy and retinitis pigmentosa.
Nicole C. L. Noel +4 more
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Plant Cryptochromes Illuminated: A Spectroscopic Perspective on the Mechanism
Frontiers in Chemistry, 2021 Plant cryptochromes are central blue light receptors for the control of land plant and algal development including the circadian clock and the cell cycle.
Lukas Goett-Zink +2 more
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Modeling inducible neuropathologies of the retina with differential phenotypes in organoids
Frontiers in Cellular Neuroscience, 2023 Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research.
Manuela Völkner +14 more
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Pharmaceuticals, 2023 Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the pharmacologic activation of PKM2 is a novel photoreceptor neuroprotective strategy.
Thomas J. Wubben +9 more
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Life Science Alliance, 2020 This study reports that activation of SARM1 causes destruction of NAD pools in photoreceptor cells of the retina and identifies a role for SARM1-dependent photoreceptor cell death in retinal degeneration.
Ema Ozaki +10 more
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A generalized equation for the calculation of receptor noise limited colour distances in n-chromatic visual systems [PDF]
Royal Society Open Science, 2017 Researchers must assess similarities and differences in colour from an animal's eye view when investigating hypotheses in ecology, evolution and behaviour.
R. C. Clark +2 more
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