Results 21 to 30 of about 194,952 (354)
Mechanisms of Photoreceptor Death in Retinitis Pigmentosa
Genes, 2020 Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is characterised by the progressive loss of retinal photoreceptors. However, RP is a highly heterogeneous disease and, while much progress has been made in developing gene ...
Fay G. Newton, R. Megaw
semanticscholar +1 more source
Cells, 2020 Photoreceptor disease results in irreparable vision loss and blindness, which has a dramatic impact on quality of life. Pathogenic mutations in RP1L1 lead to photoreceptor degenerations such as occult macular dystrophy and retinitis pigmentosa.
Nicole C. L. Noel +4 more
doaj +1 more source
Plant Cryptochromes Illuminated: A Spectroscopic Perspective on the Mechanism
Frontiers in Chemistry, 2021 Plant cryptochromes are central blue light receptors for the control of land plant and algal development including the circadian clock and the cell cycle.
Lukas Goett-Zink +2 more
doaj +1 more source
Cell Death and Differentiation, 2020 Photoreceptor apoptosis is recognized as one key pathogenesis of retinal degeneration, the counteraction of which represents a promising approach to safeguard visual function.
Chun-Lei Deng +10 more
semanticscholar +1 more source
Modeling inducible neuropathologies of the retina with differential phenotypes in organoids
Frontiers in Cellular Neuroscience, 2023 Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research.
Manuela Völkner +14 more
doaj +1 more source
Cellular mechanisms of hereditary photoreceptor degeneration - Focus on cGMP.
Progress in retinal and eye research, 2020 The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood, a problem that is exacerbated by the enormous genetic heterogeneity of this disease group.
M. Power +4 more
semanticscholar +1 more source
Photoreceptors at a glance [PDF]
Journal of Cell Science, 2015 ABSTRACT Retinal photoreceptor cells contain a specialized outer segment (OS) compartment that functions in the capture of light and its conversion into electrical signals in a process known as phototransduction. In rods, photoisomerization of 11-cis to all-trans retinal within rhodopsin triggers a biochemical cascade culminating in the ...
Robert S, Molday, Orson L, Moritz
openaire +2 more sources
Fatty acid oxidation and photoreceptor metabolic needs
Journal of Lipid Research, 2020 Photoreceptors have high energy demands and a high density of mitochondria that produce ATP through oxidative phosphorylation (OXPHOS) of fuel substrates.
Z. Fu, T. Kern, A. Hellström, L. Smith
semanticscholar +1 more source
Pharmaceuticals, 2023 Treatment options are lacking to prevent photoreceptor death and subsequent vision loss. Previously, we demonstrated that reprogramming metabolism via the pharmacologic activation of PKM2 is a novel photoreceptor neuroprotective strategy.
Thomas J. Wubben +9 more
doaj +1 more source
Life Science Alliance, 2020 This study reports that activation of SARM1 causes destruction of NAD pools in photoreceptor cells of the retina and identifies a role for SARM1-dependent photoreceptor cell death in retinal degeneration.
Ema Ozaki +10 more
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