Results 11 to 20 of about 125,005 (308)
Complement activation in retinal degeneration [PDF]
, 2016 Our aim is to investigate a common role of the complement system in the pathogenesis of retinal disease, by assessing the expression profile of complement component 3 (C3) in three mechanistically distinct models of retinal degeneration: light-damage ...
Provis, Jan +3 more
core +4 more sources
Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats
Cells, 2023 Retinal degenerative diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa, lack effective therapies. Conventional monotherapeutic approaches fail to target the multiple affected pathways in retinal degeneration.
Kabir Ahluwalia +10 more
doaj +1 more source
Microglia in Retinal Degeneration [PDF]
Frontiers in Immunology, 2019 The retina is a complex tissue with multiple cell layers that are highly ordered. Its sophisticated structure makes it especially sensitive to external or internal perturbations that exceed the homeostatic range. This necessitates the continuous surveillance of the retina for the detection of noxious stimuli.
Khalid Rashid +3 more
openaire +3 more sources
Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa. [PDF]
PLoS ONE, 2012 Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood.
Miao Chen, Ke Wang, Bin Lin
doaj +1 more source
Peripapillary Intravitreal Injection Improves AAV-Mediated Retinal Transduction
Molecular Therapy: Methods & Clinical Development, 2020 The intravitreal (IVT) injection method is a choice when targeting the inner retina for gene therapy. However, the transduction efficiency of adeno-associated virus (AAV) vectors administered by the IVT route is usually low and may be affected by several
Sanjar Batirovich Madrakhimov +5 more
doaj +1 more source
Neural Reprogramming in Retinal Degeneration [PDF]
Investigative Opthalmology & Visual Science, 2007 Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration.Excitation mapping with organic ...
Marc, Robert E +7 more
openaire +2 more sources
Journal of Neuroinflammation, 2023 Background Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal domain (BET) proteins are epigenetic
Xingfei Zhu +13 more
doaj +1 more source
Antioxidants, 2021 Erythropoietin (EPO) plays an important role in erythropoiesis by its action in blocking apoptosis of progenitor cells and protects both photoreceptors and retinal ganglion cells from induced or inherited degeneration.
Manas R. Biswal +7 more
doaj +1 more source
The roles of microglia in neural remodeling during retinal degeneration [PDF]
, 2022 Retina remodeling is a consequence of many retinal degenerative diseases that are characterized by progressive photoreceptor death. Retina remodeling involves a series of complex pathological processes, consisting of photoreceptor degeneration and ...
He, Juncai +5 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2019 Adeno-associated virus (AAV) vector-mediated gene delivery is a promising approach for therapy, but implementation in the eye currently is hampered by the need for delivering the vector underneath the retina, using surgical application into the ...
Hongman Song +5 more
doaj +1 more source