Results 21 to 30 of about 106,393 (261)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV

Cell Communication and Signaling, 2019
Background The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure.
Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park, Tae Kwann Park   +7 more
doaj   +1 more source

Targeting molecular pathways for the treatment of inherited retinal degeneration

Neural Regeneration Research, 2020
Inherited retinal degeneration is a major cause of incurable blindness characterized by loss of retinal photoreceptor cells. Inherited retinal degeneration is characterized by high genetic and phenotypic heterogeneity with several genes mutated in ...
Meltem Kutluer, Li Huang, Valeria Marigo
doaj   +1 more source

Mechanism of action of platinum nanoparticles implying from antioxidant to metabolic programming in light-induced retinal degeneration model

Redox Biology, 2023
Photoreceptors (PRs) degeneration is central to visual impairment and loss in most blind retinal diseases, including age-related macular disease (AMD) and diabetic retinopathy (DR).
Lin Su, Xiaoqun Gong, Ruiyan Fan, Tianwen Ni, Fuhua Yang, Xiaomin Zhang, Xiaorong Li   +6 more
doaj   +1 more source

Recent developments of neuroprotective agents for degenerative retinal disorders

Neural Regeneration Research, 2022
Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which are caused by a group of retinal diseases affecting various age groups, and increasingly prevalent in the ...
Kepeng Ou, Youjian Li, Ling Liu, Hua Li, Katherine Cox, Jiahui Wu, Jian Liu, Andrew D Dick   +7 more
doaj   +1 more source

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]

PLoS Genetics, 2005
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John   +6 more
doaj   +2 more sources

Retinal Degeneration in the Fly [PDF]

, 2011
Many genes are functionally equivalent between flies and humans. In addition, the same, or similar, mutations cause disease in both species. In fact, nearly three-fourths of all human disease genes have related sequences in Drosophila. The fly has a relatively small genome, made up of about 13,600 genes in four pairs of chromosomes.
openaire   +2 more sources

Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration

Cell Reports, 2020
Summary: Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction.
Kelly Mulfaul, Ema Ozaki, Nilisha Fernando, Kiva Brennan, Kathleen R. Chirco, Emma Connolly, Chris Greene, Arvydas Maminishkis, Robert G. Salomon, Mikhail Linetsky, Riccardo Natoli, Robert F. Mullins, Matthew Campbell, Sarah L. Doyle   +13 more
doaj   +1 more source

Necroptosis and Neuroinflammation in Retinal Degeneration

Frontiers in Neuroscience, 2022
Necroptosis mediates the chronic inflammatory phenotype in neurodegeneration. Receptor-interacting protein kinase (RIPK) plays a pivotal role in the induction of necroptosis in various cell types, including microglia, and it is implicated in diverse neurodegenerative diseases in the central nervous system and the retina.
Yan Tao, Yusuke Murakami, Demetrios G. Vavvas, Koh-Hei Sonoda   +3 more
openaire   +3 more sources

Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors

Cells
Three-dimensional retinal culture systems help to understand eye development and the pathology of disorders. There is a need for reporter stem cell lines to allow in vitro studies on retinal progenitors and photoreceptors and their developmental dynamics
Oleksandr Zabiegalov, Adeline Berger, Dhryata Kamdar, Kabirou Adamou, Chuanxi Tian, Martial Mbefo, Mathieu Quinodoz, Florian Udry, Carlo Rivolta, Corinne Kostic, Yvan Arsenijevic   +10 more
doaj   +1 more source

Genetic and clinical characteristics of PROM1-related retinal degeneration in Korean

Scientific Reports, 2023
This scientific report aims to comprehensively describe the genetic and clinical characteristics of PROM1-related retinal degeneration in Korean patients.
Sungsoon Hwang, Se Woong Kang, Ja-Hyun Jang, Sang Jin Kim   +3 more
doaj   +1 more source