Results 21 to 30 of about 125,005 (308)

Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

Scientific Reports, 2021
Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes ...
Michal Geva, Noga Gershoni-Emek, Luana Naia, Philip Ly, Sandra Mota, Ana Cristina Rego, Michael R. Hayden, Leonard A. Levin   +7 more
doaj   +1 more source

Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography [PDF]

, 2009
BACKGROUND: Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration.
Gesine Huber, Huber, G., Muehlfriedel, Regine, Edda Fahl, Jan Wijnholds, Beck, SC, Remé Charlotte E., Tanimoto, Naoyuki, Tanimoto Naoyuki, Pacal, M, Van de Pavert, S.A., Fischer M. Dominik, Fischer, M.D., Pacal Marek, Christian Grimm, Muehlfriedel Regine, Wenzel, Andreas, Charlotte E Remé, Charlotte E. Remé, Pacal, Marek, Serge A van de Pavert, M. Dominik Fischer, Rod Bremner, Wenzel, A., Bremner Rod, Remé, Charlotte E, Fischer, M Dominik, Susanne C. Beck, Huber, Gesine, Wijnholds, J, Fahl, E, Beck, S.C., Marek Pacal, Grimm Christian, Wenzel, A, Regine Muehlfriedel, Huber Gesine, Wijnholds, Jan, Tanimoto, N, Bremner, R., Reme, C.E., Wijnholds, Jan; https://orcid.org/, Bremner, R, Seeliger Mathias W., Beck, Susanne C., Fischer, M. Dominik, Mathias W Seeliger, Wijnholds Jan, Bremner, Rod, van de Pavert Serge A., M Dominik Fischer, Andreas Wenzel, Mühlfriedel, Regine, Tanimoto, N., Fahl, E., Seeliger, Mathias W, Fischer, Manuel, Beck Susanne C., Seeliger, Mathias W., Remé, Charlotte E., Van De Pavert, SA, Fahl, Edda, Pacal, M., Remé, CE, van de Pavert, Serge A., Beck, Susanne C; https://orcid.org/, Huber, G, Grimm, C., Seeliger, MW, Wenzel Andreas, Fahl Edda, Mathias W. Seeliger, Pavert, S.A. van de, Grimm, C, Grimm, Christian, Grimm, Christian; https://orcid.org/, Muehlfriedel, R., Serge A. Van De Pavert¤b, Wijnholds, J., van de Pavert, Serge A, Susanne C Beck, Fischer, MD, Muehlfriedel, R, Seeliger, M.W., Naoyuki Tanimoto   +84 more
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Targeting molecular pathways for the treatment of inherited retinal degeneration

Neural Regeneration Research, 2020
Inherited retinal degeneration is a major cause of incurable blindness characterized by loss of retinal photoreceptor cells. Inherited retinal degeneration is characterized by high genetic and phenotypic heterogeneity with several genes mutated in ...
Meltem Kutluer, Li Huang, Valeria Marigo
doaj   +1 more source

Assessing the role of T cells in response to retinal injury to uncover new therapeutic targets for the treatment of retinal degeneration

Journal of Neuroinflammation, 2023
Background Retinal degeneration is a disease affecting the eye, which is an immune-privileged site because of its anatomical and physiological properties.
Federica M. Conedera, Judith M. Runnels, Jens V. Stein, Clemens Alt, Volker Enzmann, Charles P. Lin   +5 more
doaj   +1 more source

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV

Cell Communication and Signaling, 2019
Background The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure.
Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park, Tae Kwann Park   +7 more
doaj   +1 more source

An Unusual Case of Extensive Lattice Degeneration and Retinal Detachment [PDF]

Journal of Clinical and Diagnostic Research, 2016
Lattice degeneration of the retina is not infrequently encountered on a dilated retinal examination and many of them do not need any intervention. We report a case of atypical lattice degeneration variant with peripheral retinal detachment.
David J. Mathew, Saurabh Kumar Sarma, Jennifer V. Basaiawmoit   +2 more
doaj   +1 more source

Mechanism of action of platinum nanoparticles implying from antioxidant to metabolic programming in light-induced retinal degeneration model

Redox Biology, 2023
Photoreceptors (PRs) degeneration is central to visual impairment and loss in most blind retinal diseases, including age-related macular disease (AMD) and diabetic retinopathy (DR).
Lin Su, Xiaoqun Gong, Ruiyan Fan, Tianwen Ni, Fuhua Yang, Xiaomin Zhang, Xiaorong Li   +6 more
doaj   +1 more source

Novel rodent models for macular research [PDF]

, 2010
BACKGROUND: Many disabling human retinal disorders involve the central retina, particularly the macula. However, the commonly used rodent models in research, mouse and rat, do not possess a macula.
Gesine Huber, Muehlfriedel, Regine, Huber, G., Feng, Yuxi, Seeliger, M., Tanimoto, Naoyuki, Tanimoto Naoyuki, Severin Heynen, Hans-Peter Hammes, Christian Grimm, Feng, Y., Imsand Coni, Imsand, Coni, Muehlfriedel Regine, Susanne C. Beck, Huber, Gesine, Heynen, S., Grimm Christian, Regine Muehlfriedel, Huber Gesine, vom Hagen Franziska, Coni Imsand, Imsand, C., Seeliger Mathias W., Mühlfriedel, R., Peichl, Leo, Mathias W Seeliger, vom Hagen, F., Mühlfriedel, Regine, Tanimoto, N., Heynen Severin, Hammes, Hans-Peter, Seeliger, Mathias W, Beck Susanne C., Seeliger, Mathias W., Peichl Leo, Yuxi Feng, Peichl, L., Beck, Susanne C; https://orcid.org/, Grimm, C., Feng Yuxi, Mathias W. Seeliger, Leo Peichl, Franziska vom Hagen, Grimm, Christian, Grimm, Christian; https://orcid.org/, vom Hagen, Franziska, Beck, S., Beck, Susanne Christiane, Hammes Hans-Peter, Susanne C Beck, Naoyuki Tanimoto, Hammes, H., Heynen, Severin   +53 more
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Recent developments of neuroprotective agents for degenerative retinal disorders

Neural Regeneration Research, 2022
Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which are caused by a group of retinal diseases affecting various age groups, and increasingly prevalent in the ...
Kepeng Ou, Youjian Li, Ling Liu, Hua Li, Katherine Cox, Jiahui Wu, Jian Liu, Andrew D Dick   +7 more
doaj   +1 more source

Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]

, 2012
The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Johannes Burger, Yu, Alice L., Burger, Johannes, Welge-Lussen, Ulrich, Alice L Yu, Kerstin Birke, Birke, Kerstin, Alice L. Yu, Ulrich Welge-Lussen   +8 more
core   +1 more source