Results 21 to 30 of about 517,479 (253)

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179 [PDF]

, 2015
The rd1 mouse with a mutation in the Pde6b gene was the first strain of mice identified with a retinal degeneration. However, AAV-mediated gene supplementation of rd1 mice only results in structural preservation of photoreceptors, and restoration of the ...
Bainbridge, James W.B., Rizzi, M, Nishiguchi, KM, James W. B. Bainbridge, Kate Powell, Joana Ribeiro, Duran, Y, Ribeiro, J, Powell, K, Luhmann, UF, Azam, Selina A., Yanai Duran, Rizzi, Matteo, Livia S. Carvalho, Smith, Alexander J., Holthaus, Sophia Martha Kleine, Robin R. Ali, Ulrich F. O. Luhmann, Carvalho, Livia S., Er J. Smith, Koji M. Nishiguchi, Powell, Kate, Matteo Rizzi, Selina A. Azam, Carvalho, LS, Ali, RR, Holthaus, SM, Sophia-martha Kleine Holthaus, Bainbridge, JW, Ali, Robin R.; id_orcid, Luhmann, Ulrich F.O., Duran, Yanai, Azam, SA, Ribeiro, Joana, Smith, AJ, Nishiguchi, Koji M.   +35 more
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Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. [PDF]

PLoS ONE, 2014
Cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration.
Blanca Arango-Gonzalez, Dragana Trifunović, Ayse Sahaboglu, Katharina Kranz, Stylianos Michalakis, Pietro Farinelli, Susanne Koch, Fred Koch, Sandra Cottet, Ulrike Janssen-Bienhold, Karin Dedek, Martin Biel, Eberhart Zrenner, Thomas Euler, Per Ekström, Marius Ueffing, François Paquet-Durand   +16 more
doaj   +1 more source

Topographic mapping of retinal function with the SLO-mfERG under simultaneous control of fixation in Best's disease [PDF]

, 2003
Purpose: To introduce the scanning laser ophthalmoscope-evoked mfERG (SLO-mfERG) as a new method to measure focal retinal function. Methods: Sixty-two healthy individuals and 12 patients with Best's disease were examined.
Kalpadakis, P., Rudolph, G.
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Pearls and Pitfalls of Adaptive Optics Ophthalmoscopy in Inherited Retinal Diseases

Diagnostics, 2023
Adaptive optics (AO) retinal imaging enables individual photoreceptors to be visualized in the clinical setting. AO imaging can be a powerful clinical tool for detecting photoreceptor degeneration at a cellular level that might be overlooked through ...
Helia Ashourizadeh, Maryam Fakhri, Kiana Hassanpour, Ali Masoudi, Sattar Jalali, Danial Roshandel, Fred K. Chen   +6 more
doaj   +1 more source

The detrimental effects of progression of retinal degeneration in the visual cortex

Frontiers in Cellular Neuroscience, 2022
The leading cause of blindness in inherited and age-related retinal degeneration (RD) is the death of retinal photoreceptors such as rods and cones.
Anwesha Bhattacharyya
doaj   +1 more source

Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography [PDF]

, 2009
BACKGROUND: Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration.
Gesine Huber, Huber, G., Muehlfriedel, Regine, Edda Fahl, Jan Wijnholds, Beck, SC, Remé Charlotte E., Tanimoto, Naoyuki, Tanimoto Naoyuki, Pacal, M, Van de Pavert, S.A., Fischer M. Dominik, Fischer, M.D., Pacal Marek, Christian Grimm, Muehlfriedel Regine, Wenzel, Andreas, Charlotte E Remé, Charlotte E. Remé, Pacal, Marek, Serge A van de Pavert, M. Dominik Fischer, Rod Bremner, Wenzel, A., Bremner Rod, Remé, Charlotte E, Fischer, M Dominik, Susanne C. Beck, Huber, Gesine, Wijnholds, J, Fahl, E, Beck, S.C., Marek Pacal, Grimm Christian, Wenzel, A, Regine Muehlfriedel, Huber Gesine, Wijnholds, Jan, Tanimoto, N, Bremner, R., Reme, C.E., Wijnholds, Jan; https://orcid.org/, Bremner, R, Seeliger Mathias W., Beck, Susanne C., Fischer, M. Dominik, Mathias W Seeliger, Wijnholds Jan, Bremner, Rod, van de Pavert Serge A., M Dominik Fischer, Andreas Wenzel, Mühlfriedel, Regine, Tanimoto, N., Fahl, E., Seeliger, Mathias W, Fischer, Manuel, Beck Susanne C., Seeliger, Mathias W., Remé, Charlotte E., Van De Pavert, SA, Fahl, Edda, Pacal, M., Remé, CE, van de Pavert, Serge A., Beck, Susanne C; https://orcid.org/, Huber, G, Grimm, C., Seeliger, MW, Wenzel Andreas, Fahl Edda, Mathias W. Seeliger, Pavert, S.A. van de, Grimm, C, Grimm, Christian, Grimm, Christian; https://orcid.org/, Muehlfriedel, R., Serge A. Van De Pavert¤b, Wijnholds, J., van de Pavert, Serge A, Susanne C Beck, Fischer, MD, Muehlfriedel, R, Seeliger, M.W., Naoyuki Tanimoto   +84 more
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Metabolism Dysregulation in Retinal Diseases and Related Therapies

Antioxidants, 2022
The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids.
Yingying Chen, Nathan J. Coorey, Meixia Zhang, Shaoxue Zeng, Michele C. Madigan, Xinyuan Zhang, Mark C. Gillies, Ling Zhu, Ting Zhang   +8 more
doaj   +1 more source

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. [PDF]

PLoS Genetics, 2005
In glaucoma, harmful intraocular pressure often contributes to retinal ganglion cell death. It is not clear, however, if intraocular pressure directly insults the retinal ganglion cell axon, the soma, or both.
Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John   +6 more
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Progressive retinal degeneration and glial activation in the Cln6nclf mouse model of neuronal ceroid lipofuscinosis : a beneficial effect of DHA and Curcumin supplementation [PDF]

, 2013
Neuronal ceroid lipofuscinosis (NCL) is a group of neurodegenerative lysosomal storage disorders characterized by vision loss, mental and motor deficits, and spontaneous seizures.
Monica Langiu, Myriam Mirza, Langiu, Monica, Tamm, Ernst R., Mirza, Myriam, Langmann, Thomas, Ernst R. Tamm, Aleksandra Somogyi, Marcus Karlstetter, Mika O. Ruonala, Volz, Cornelia, Jägle, Herbert, Herbert Jägle, Ernst R Tamm, Somogyi, Aleksandra, Cornelia Volz, Thomas Langmann, Mika O Ruonala, Karlstetter, Marcus, Ruonala, Mika O.   +19 more
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The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration

PLoS Biology, 2022
Inherited retinal degeneration due to loss of photoreceptor cells is a leading cause of human blindness. These cells possess a photosensitive outer segment linked to the cell body through the connecting cilium (CC).
Olivier Mercey, Corinne Kostic, Eloïse Bertiaux, Alexia Giroud, Yashar Sadian, David C. A. Gaboriau, Ciaran G. Morrison, Ning Chang, Yvan Arsenijevic, Paul Guichard, Virginie Hamel   +10 more
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