Results 11 to 20 of about 517,479 (253)

Statistical modelling of neuron degeneration [PDF]

open access: yes, 2013
SUMMARY: Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease are all examples of neurodegenerative disorders that result from the premature death of nerve cells or neurons.
Henderson, Robert   +3 more
core   +4 more sources

Monitoring Visual Cortical Activities During Progressive Retinal Degeneration Using Functional Bioluminescence Imaging

open access: yesFrontiers in Neuroscience, 2021
Mouse models of inherited retinal degenerative diseases such as retinitis pigmentosa are characterized by degeneration of photoreceptors, which hinders the generation of signal to be transmitted to the visual cortex.
Darryl Narcisse   +6 more
doaj   +1 more source

The Evolution of Fabrication Methods in Human Retina Regeneration

open access: yesApplied Sciences, 2021
Optic nerve and retinal diseases such as age-related macular degeneration and inherited retinal dystrophies (IRDs) often cause permanent sight loss. Currently, a limited number of retinal diseases can be treated.
Beatrice Belgio   +3 more
doaj   +1 more source

Effect of purified murine NGF on isolated photoreceptors of a rodent developing retinitis pigmentosa. [PDF]

open access: yesPLoS ONE, 2015
A number of different studies have shown that neurotrophins, including nerve growth factor (NGF) support the survival of retinal ganglion neurons during a variety if insults.
Maria Luisa Rocco   +4 more
doaj   +1 more source

Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium

open access: yesAntioxidants, 2021
Erythropoietin (EPO) plays an important role in erythropoiesis by its action in blocking apoptosis of progenitor cells and protects both photoreceptors and retinal ganglion cells from induced or inherited degeneration.
Manas R. Biswal   +7 more
doaj   +1 more source

Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways

open access: yesNeurobiology of Disease, 2011
Cerium oxide nanoparticles, nanoceria, are inorganic antioxidants that have catalytic activities which mimic those of the neuroprotective enzymes superoxide dismutase and catalase.
Li Kong   +6 more
doaj   +1 more source

Induced pluripotent stem cells and derivative photoreceptor precursors as therapeutic cells for retinal degenerations

open access: yesTzu Chi Medical Journal, 2020
The visual impairment associated with inherited retinal degeneration and age-related degeneration of photoreceptors is causing substantial challenges in finding effective therapies.
Rupendra Shrestha   +2 more
doaj   +1 more source

Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration [PDF]

open access: yes, 2009
To describe the 2- to 4-year visual and microperimetry outcomes of autologous retinal pigment epithelium (RPE)-choroid graft in patients with neovascular age-related macular degeneration (AMD).In this retrospective cohort study, 12 patients with ...
Coffey, PJ   +9 more
core   +1 more source

Novel stem cell and gene therapy in diabetic retinopathy, age related macular degeneration, and retinitis pigmentosa

open access: yesInternational Journal of Retina and Vitreous, 2019
Degenerative retinal disease leads to significant visual morbidity worldwide. Diabetic retinopathy and macular degeneration are leading causes of blindness in the developed world.
Parker E. Ludwig   +2 more
doaj   +1 more source

Cell-based assays to identify novel retinoprotective agents

open access: yesMethodsX, 2020
Degeneration of the retina can lead ultimately to devastating irreversible vision loss, such as in inherited retinitis pigmentosa and age-related macular degeneration. Currently there is no cure to prevent retinal degeneration.
Jeanee Bullock   +2 more
doaj   +1 more source

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