Results 31 to 40 of about 517,479 (253)

Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens [PDF]

, 2006
PURPOSE. To identify the gene defect that causes blindness and the predisposition to embryonic death in the retinopathy globe enlarged (rge) chicken.METHODS. Linkage analysis, with previously uncharacterized microsatellite markers from chicken chromosome
Hocking, Paul M., Tummala, Hemanth, Getty, Paul, Ali, Manir, Burt, David W., Inglehearn, Chris F., Lester, Douglas H.   +6 more
core   +1 more source

A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina. [PDF]

, 2015
Our understanding of the relevance of peripheral retinal abnormalities to disease in general and in age-related macular degeneration (AMD) in particular is limited by the lack of detailed peripheral imaging studies.
Lengyel, Imre, Florea, D, Lengyel, I, Csutak, Adrienne, Peto, Tunde, Peto, T, Leung, I, Bird, AC, Florea, Daniela, Csutak, A, Bird, Alan C., Jonasson, Fridbert, Leung, Irene, Jonasson, F   +13 more
core   +1 more source

Minocycline decreases CCR2-positive monocytes in the retina and ameliorates photoreceptor degeneration in a mouse model of retinitis pigmentosa.

PLoS ONE, 2021
Retinal inflammation accelerates photoreceptor cell death caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has been previously reported to rescue photoreceptor cell death in retinal degeneration.
Ryo Terauchi, Hideo Kohno, Sumiko Watanabe, Saburo Saito, Akira Watanabe, Tadashi Nakano   +5 more
doaj   +1 more source

Late-Onset Retinal Degeneration: Clinical Perspectives

Clinical Ophthalmology, 2022
Leonardo Lando,1,2 Shyamanga Borooah1 1Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA; 2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, CanadaCorrespondence: Shyamanga Borooah, Shiley Eye ...
Lando L, Borooah S
doaj  

Early stages of retinal development depend on Sec13 function [PDF]

, 2013
ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Feng, Yi, Schmidt, Katy, Stephens, David J, Yi Feng, Katy Schmidt, David J. Stephens, Florencia Cavodeassi, Cavodeassi, Florencia   +7 more
core   +1 more source

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo [PDF]

, 2012
Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization.
David-Alexandre Tregouet (4350982), Florian Sennlaub (64439), Xavier Guillonneau, William Raoul (64427), Sophie Krumeich (177422), Sophie Krumeich, Raoul William, Théry Clotilde, Calippe Bertrand, Salomon-Yves Cohen, Poupel Lucie, Camelo, Serge, Xavier Guillonneau (64430), Bertrand Calippe, Behar-Cohen Francine, Tregouet, David-Alexandre, Baatz, Holger, Bertrand Calippe (177425), Florian Sennlaub, Lucie Poupel, Francine Behar-Cohen, Théry, Clotilde, Sophie Lavalette (64428), Serge Camelo (177419), Calippe, Bertrand, Cohen Salomon-Yves, Lavalette Sophie, Behar-Cohen, Francine, Clotilde Théry (177438), Lavalette, Sophie, Tregouet David-Alexandre, Christophe Combadière, Combadière Christophe, Raoul, William, William Raoul, Sennlaub Florian, Salomon-Yves Cohen (177429), Baatz Holger, Guillonneau, Xavier, Nicole Keller, Keller, Nicole, Guillonneau Xavier, Camelo Serge, Nicole Keller (64429), Keller Nicole, Cohen, Salomon-Yves, David-Alexandre Tregouet, Serge Camelo, Sophie Lavalette, Holger Baatz (177431), Krumeich Sophie, Christophe Combadière (177434), Sennlaub, Florian, Combadière, Christophe, Poupel, Lucie, Krumeich, Sophie, Lucie Poupel (177410), Holger Baatz, Clotilde Théry, Francine Behar-Cohen (64434), Behar-Cohen, F., Krumeich, S., Camelo, S., Combadière, C., Guillonneau, X., Baatz, H., Sennlaub, F., Calippe, B., Poupel, L., Théry, C., Keller, N., Lavalette, S., Cohen, S.Y., Tregouet, D.A., Raoul, W.   +74 more
core   +1 more source

Poly(ADP-ribose) polymerase regulates transient receptor potential channel M2-dependent calpain activation in rd1 mouse retinal degeneration

Neural Regeneration Research
Inherited retinal degeneration refers to untreatable blinding diseases characterized by progressive photoreceptor loss. Photoreceptor degeneration is often associated with an excessive activation of poly(ADP-ribose) polymerase and Ca2+-dependent calpain ...
Jie Yan, Lei Kong, Zhijian Zhao, Qianlu Yang, Lan Wang, Qianxi Yang, Christian Harteneck, Kangwei Jiao, Zhulin Hu, François Paquet-Durand   +9 more
doaj   +1 more source

Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]

, 2015
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB, Pearson, RA, Hippert, C, Barber, AC, West, EL, Smith, AJ, Ali, RR   +6 more
core  

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Dimitrios Stampoulis, M. Francesca Cordeiro, Williams, JA, Jennifer A. E. Williams, Stampoulis, D, Li Guo, Shi, H, Guo, L, Moss, SE, Francesca Cordeiro, M, Stephen E. Moss, Hui Shi   +11 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source