Results 211 to 220 of about 48,210 (290)

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

Macromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani, José Hurst, Malte Ritter, Philipp Weingarten, Julia Skokowa, Sven Schnichels, Friederike Adams   +6 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Addressing Challenges in Developing Treatments for Inherited Retinal Diseases: Recommendations From the Third Monaciano Symposium. [PDF]

Transl Vis Sci Technol
Thompson DA, Jayasundera KT, Alekseev O, Ali RR, Amato A, Arshavsky VY, Audo IS, Auricchio A, Bainbridge JWB, Banin E, Besirli CG, Birch DG, Branham KE, Cideciyan AV, Daiger SP, Duncan JL, Fahim AT, Flannery JG, Gattegna R, Heckenlively JR, Héon E, Iannaccone A, Khan NW, Khateb S, Klassen HJ, Leroy BP, Marangoni D, Michaelides M, Musch DC, Pennesi ME, Petersen-Jones SM, Pierce EA, Rao RC, Sahel JA, Sieving PA, Strettoi E, Strong CR, Wubben TJ, Yang P, Zacks DN, Monaciano Consortium.   +40 more
europepmc   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Exploring Concomitant Ophthalmic Comorbidities in Portuguese Patients with Inherited Retinal Diseases: A Comprehensive Clinical Study. [PDF]

Genes (Basel)
Mesquita R, Marta A, Marques-Couto P, Costa J, Estrela-Silva S, Cabral D, Marques JP, Vaz-Pereira S.   +7 more
europepmc   +1 more source

The Application of Telemedicine in Surgery

Med Research, EarlyView.
This figure provides an overview of the content presented in this article. Telemedicine is integrated throughout the entire surgical workflow, with distinct applications across the preoperative, intraoperative, and postoperative phases. These applications are enabled by a suite of supporting technologies, while the associated implementation challenges ...
Yufan Yang, Chang Liu, Xue Sun, Yiting Wang, Minghui Zhao, Shuya Jiang, Haoling Zhang, Wangzheqi Zhang, Wenwen Shi   +8 more
wiley   +1 more source

A comprehensive genetic landscape of inherited retinal diseases in a large Pakistani cohort. [PDF]

NPJ Genom Med
Ullah M, Rehman AU, Quinodoz M, Rashid A, Cancellieri F, Munir A, Kaminska K, Iqbal A, Javed S, Dawood M, Baig HMA, Saleha S, Naz S, Kausar H, Waryah AM, Superti-Furga A, Ansar M, Rivolta C.   +17 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Correction: Canine models of inherited retinal diseases: from neglect to well-recognized translational value. [PDF]

Mamm Genome
Dufour VL, Aguirre GD.
europepmc   +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

Medicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang, Leilei Zhai, Chan Huang, Liqin Li, Yong Wang, Jiaojiao Fan, Wei Zhou   +6 more
wiley   +1 more source