Results 61 to 70 of about 2,460,078 (269)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations

Stem Cell Research, 2020
Inherited retinal diseases (IRDs) are clinically and genetically heterogenous diseases affecting the neural retina and retinal pigment epithelium resulting in irreversible blindness.
Vijay Bhaskar Reddy Konala, Swapna Nandakumar, Rajani Battu, Rajarshi Pal   +3 more
doaj   +1 more source

Preface of Special Issue "Molecular Therapies for Inherited Retinal Diseases" [PDF]

, 2020
Contains fulltext : 218308.pdf (Publisher’s version ) (Open Access)Inherited retinal diseases (IRDs) are a group of progressive disorders that lead to severe visual impairment or even complete blindness.
Collin, R.W.J., Alejandro Garanto, Garanto, A., Rob W.J. Collin   +3 more
core   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

A psychosocial portrait of diagnosis and treatment in families of patients with inherited retinal diseases: an analysis based on in-depth interviews with patients and their family members

Yanke Xuebao
Objective: Inherited retinal diseases not only impose physical burdens on patients but also inflict psychological distress on their families. This study aims to investigate how the diagnosis and treatment process affects the psychological well-being of ...
CHEN Mengyao, DUAN Zhaoyan, YANG Panwang, XIE Liang, YANG Zhisheng, ZHANG Yudi   +5 more
doaj   +1 more source

Optical Coherence Tomography Angiography Imaging in Inherited Retinal Diseases

, 2019
Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging modality that allows depth-resolved imaging of the microvasculature in the retina and the choroid.
Ong, Singh, Patel
core   +1 more source

Stem cell-based therapeutic applications in retinal degenerative diseases [PDF]

, 2010
Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa ...
Suzanne T Ildstad, Enzmann, Volker, Yiming Huang, Volker Enzmann, Huang, Yiming, Ildstad, Suzanne T, Suzanne T. Ildstad   +6 more
core   +2 more sources

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Update on the Management of ABCA4 Retinopathy (Stargardt Disease)

Ophthalmology and Therapy
ABCA4-associated retinopathies (Stargardt disease) are the most common inherited macular dystrophy and a leading cause of early onset central vision loss.
Deepika C. Parameswarappa, Dhanashree Ratra, Goura Chattannavar, Srikanta Kumar Padhy   +3 more
doaj   +1 more source