Results 41 to 50 of about 2,460,078 (269)
Emerging Drug Therapies for Inherited Retinal Dystrophies
, 2020 Worldwide, 1 in 2000 people suffer from inherited retinal dystrophies (IRD). Individuals with IRD typically present with progressive vision loss that ultimately results in blindness. Unfortunately, effective treatment options are not widely available due
Sundaramurthi, Husvinee
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, 2020 Inherited retinal diseases (IRDs) are a diverse and variable group of rare human disorders [...
Jamie M. Ellingford +2 more
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Inherited retinal diseases in Indigenous peoples: A scoping review
, 2023 This scoping review aims to identify and synthesise studies evaluating the prevalence and diagnosis of inherited retinal diseases among Indigenous peoples ...
Alexis Ceecee Britten-Jones +1 more
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Cellular and Molecular Mechanisms of Pathogenesis Underlying Inherited Retinal Dystrophies
Biomolecules, 2023 Inherited retinal dystrophies (IRDs) are congenital retinal degenerative diseases that have various inheritance patterns, including dominant, recessive, X-linked, and mitochondrial.
Andrew Manley +3 more
doaj +1 more source
Ophthalmology and Therapy, 2020 Patient safety is a primary priority in the conduction of retinal gene therapy trials. An understanding of risk factors and mitigation strategies for post-procedure complications is crucial for the optimization of gene therapy clinical trial protocols ...
Yan Nuzbrokh +4 more
doaj +1 more source
Telegenetics for inherited retinal diseases in the COVID-19 environment
International Journal of Retina and Vitreous, 2021 Inherited retinal diseases (IRDs) are visually debilitating conditions that affect families worldwide. They require extensive clinical testing, examination, and patient and family counseling, which are frequently accomplished over single-day extended ...
Ahmad Al-Moujahed +4 more
doaj +1 more source
Advancing precision medicines for ocular disorders: Diagnostic genomics to tailored therapies
Frontiers in Medicine, 2022 Successful sequencing of the human genome and evolving functional knowledge of gene products has taken genomic medicine to the forefront, soon combining broadly with traditional diagnostics, therapeutics, and prognostics in patients.
Priyalakshmi Panikker +4 more
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Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens [PDF]
, 2006 PURPOSE. To identify the gene defect that causes blindness and the predisposition to embryonic death in the retinopathy globe enlarged (rge) chicken.METHODS. Linkage analysis, with previously uncharacterized microsatellite markers from chicken chromosome
Hocking, Paul M. +6 more
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In vivo application of base and prime editing to treat inherited retinal diseases
, 2023 Inherited retinal diseases (IRDs) are vision-threatening retinal disorders caused by pathogenic variants of genes related to visual functions. Genomic analyses in patients with IRDs have revealed pathogenic variants which affect vision.
김형범
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Genome editing, a superior therapy for inherited retinal diseases. [PDF]
, 2023 Gene augmentation and genome editing are promising strategies for the treatment of monogenic inherited retinal diseases. Although gene augmentation treatments are commercially available for inherited retinal diseases, there are many shortcomings that ...
Du, Samuel +2 more
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