Results 31 to 40 of about 2,460,078 (269)
Retinal imaging in inherited retinal diseases
Annals of Eye Science, 2020 Inherited retinal diseases (IRD) are a leading cause of blindness in the working age population. The advances in ocular genetics, retinal imaging and molecular biology, have conspired to create the ideal environment for establishing treatments for IRD, with the first approved gene therapy and the commencement of multiple therapy trials.
Georgiou, Michalis +2 more
openaire +2 more sources
Gene therapy for inherited retinal diseases [PDF]
Annals of Translational Medicine, 2021 Inherited retinal diseases (IRDs) are a genetically variable collection of devastating disorders that lead to significant visual impairment. Advances in genetic characterization over the past two decades have allowed identification of over 260 causative mutations associated with inherited retinal disorders. Thought to be incurable, gene supplementation
Nuzbrokh, Yan +2 more
openaire +2 more sources
Inherited retinal diseases in Norway - Studies on phenotype and genotype characteristics
, 2021 Inherited retinal diseases are a leading cause of vision loss in children and young adults. The majority of inherited retinal diseases are untreatable, consequently leading to irreversible retinal damage and blindness.
Holtan, Josephine Prener
core +1 more source
Frontiers in Transplantation, 2023 Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa.
Davinia Beaver, Ioannis Jason Limnios
doaj +1 more source
Gene Therapy to the Retina and the Cochlea
Frontiers in Neuroscience, 2021 Vision and hearing disorders comprise the most common sensory disorders found in people. Many forms of vision and hearing loss are inherited and current treatments only provide patients with temporary or partial relief.
Ryan Crane +8 more
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Topographic mapping of retinal function with the SLO-mfERG under simultaneous control of fixation in Best's disease [PDF]
, 2003 Purpose: To introduce the scanning laser ophthalmoscope-evoked mfERG (SLO-mfERG) as a new method to measure focal retinal function. Methods: Sixty-two healthy individuals and 12 patients with Best's disease were examined.
Kalpadakis, P., Rudolph, G.
core +1 more source
Early stages of retinal development depend on Sec13 function [PDF]
, 2013 ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Feng, Yi +7 more
core +1 more source
Developing Non-Human Primate Models of Inherited Retinal Diseases
, 2022 Inherited retinal diseases (IRDs) represent a genetically and clinically heterogenous group of diseases that can eventually lead to blindness. Advances in sequencing technologies have resulted in better molecular characterization and genotype&ndash ...
Xinyi Su +3 more
core +1 more source
The Evolution of Fabrication Methods in Human Retina Regeneration
Applied Sciences, 2021 Optic nerve and retinal diseases such as age-related macular degeneration and inherited retinal dystrophies (IRDs) often cause permanent sight loss. Currently, a limited number of retinal diseases can be treated.
Beatrice Belgio +3 more
doaj +1 more source
Therapeutic landscape for inherited ocular diseases: current and emerging therapies
Singapore Medical Journal, 2023 Inherited ocular diseases comprise a heterogeneous group of rare and complex diseases, including inherited retinal diseases (IRDs) and inherited optic neuropathies.
Hwei Wuen Chan, Jaslyn Oh, Bart Leroy
doaj +1 more source