Results 121 to 130 of about 6,398,774 (357)

Effect of diethylstilbestrol on skin sterols of the male rat

Journal of Lipid Research, 1968
Diethylstilbestrol (DES) was injected in doses ranging from 600 μg to 0.4 μg/kg body weight into mature male rats over a 3 wk period. Profound effects on skin morphology and on sterol content of skin were noted.
L. Horlick
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial

Clinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das, Antoinette (Toni) Ajavon‐Hartmann, Virginia (Ginny) D. Schmith   +2 more
doaj   +1 more source

Enzyme Inhibition [PDF]

Nature, 1954
P C, SPENSLEY, H J, ROGERS
openaire   +2 more sources

Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]

, 2007
Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition ...
Candelario-Jalil, Eduardo, Fiebich, Bernd, Garcia-Cabrera, Michel, Gonzalez-Falcon, Armando, Leon, Olga Sonia   +4 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Age Effect on Automatic Inhibitory Function of the Somatosensory and Motor Cortex: An MEG Study

Frontiers in Aging Neuroscience, 2018
Age-related deficiency in the top-down modulation of cognitive inhibition has been extensively documented, whereas the effects of age on a bottom-up or automatic operation of inhibitory function were less investigated.
Chia-Hsiung Cheng, Chia-Hsiung Cheng, Chia-Hsiung Cheng, Chia-Hsiung Cheng, Mei-Yin Lin, Mei-Yin Lin, Shiou-Han Yang, Shiou-Han Yang   +7 more
doaj   +1 more source

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Nature Medicine, 2019
Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS1–4.
C. Kinsey, S. Camolotto, A. Boespflug, Katrin P. Guillen, M. Foth, A. Truong, Sophia Schuman, Jill E. Shea, M. Seipp, Jeffrey Yap, Lance D. Burrell, David H. Lum, Jonathan R. Whisenant, G. W. Gilcrease, Courtney C. Cavalieri, Kaitrin M. Rehbein, Stephanie L. Cutler, Kajsa E. Affolter, A. Welm, B. Welm, Courtney L. Scaife, Eric L. Snyder, M. McMahon   +22 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Allelopathic Effects of Moringa oleifera Lam. on Cultivated and Non-Cultivated Plants: Implications for Crop Productivity and Sustainable Agriculture

Agronomy
Moringa (Moringa oleifera Lam.) is widely recognised as a multipurpose crop suitable for human and animal consumption, medicinal, and industrial purposes, making it attractive for introduction into new ranges.
Blair Moses Kamanga, Donita L. Cartmill, Craig McGill, Andrea Clavijo McCormick   +3 more
doaj   +1 more source