Results 231 to 240 of about 6,398,774 (357)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

PD-1/LAG-3 signaling rewires T-cells via MYC inhibition. [PDF]

Signal Transduct Target Ther
Chocarro L, Fernández-Rubio L, Ausin K, Blanco E, Echaide M, Vilaplana B, Santamaría E, Fernández-Irigoyen J, Kochan G, Escors D.   +9 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Diethylenetriamine-driven assembly of a dimeric cadmium bromide hybrid and an organic bromide salt: structural, vibrational, optical, <i>in silico</i> study and biological insights. [PDF]

RSC Adv
Ben Mahmoud I, Alghamdi MA, Lazreg Aref H, Mhadhbi N, Nasrallah HH, Guesmi A, Ben Hamadi N, Walha S, Costantino F, Naïli H.   +9 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Spatially targeted inhibitory rhythms differentially affect neuronal integration. [PDF]

Elife
Headley DB, Latimer B, Aberbach A, Nair SS.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Nature Medicine, 2019
Kirsten L. Bryant, Clint A. Stalnecker, Daniel Zeitouni, Jennifer E. Klomp, S. Peng, A. Tikunov, V. Gunda, M. Pierobon, Andrew M. Waters, Samuel D. George, Garima Tomar, Bjoern Papke, G. A. Hobbs, Liang Yan, T. Hayes, J. Diehl, G. Goode, Nina V. Chaika, Yingxue Wang, Guo-Fang Zhang, A. Witkiewicz, E. Knudsen, E. Petricoin, P. Singh, J. Macdonald, N. Tran, C. Lyssiotis, Haoqiang Ying, Alec C. Kimmelman, A. Cox, C. Der   +30 more
semanticscholar   +1 more source

Evaluating FABP5 as a Therapeutic Target for Pain Management. [PDF]

Eur J Pain
Warren W, Osborn M, Kaczocha M, Yates A, O'Sullivan S.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source