Results 141 to 150 of about 614,259 (306)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Facile Preparation of AT-PEG Polymer and Its Corrosion Inhibition Performance

, 2017
Aniline tetramer grafted polyethylene glycol methyl ether (AT-PEG) was obtained from aniline tetramer (AT), polyethylene glycol (PEG) and toluene-2,4-diisocyanate (TDI).
Peng, Wanjun, Zhao, Hongran, Yu, Haibin, Ding, Jiheng   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

ELECTROCHEMICAL STUDIES OF THE INHIBITING EFFICIENCY OF ANTICORROSION COATINGS

Journal of Contemporary Business Law & Technology: Cyber Law, Blockchain, and Legal Innovations
In this article, the polarization curves of anti-corrosion coatings are studied. Corrosion analysis of bare and coated substrates was performed using a CS-350 potentiostat system connected to corrosion analysis software. Polarization measurements were carried out potentiostatically at room temperature using an Ag/AgCl/Cl- (0.222 V) reference electrode ...
Kodirov N.U, Beknazarov Kh.S, Ibragimov B.T.   +2 more
openaire   +1 more source

INVESTIGATION FOR OPTIMAL INHIBITION EFFICIENCY AGAINST MILD-CARBON STEEL CORRRSIONIN0.1 M ACIDIC MEDIA USING CASHEW EXTRACT [PDF]

, 2015
Corrosion is an everyday challenge in all sectors of the economy particularly the manufacturing industry and this has led to massive economic loss. Literature is sparse on optimal Inhibition efficiency from Hydrochloric acid (HCl) and Tetra-oxo-sulphate (
Akinmoladun, A. I., Bello, J. O., Neil, Phillip, Oyawale, F. A., Olawale, O.   +4 more
core  

Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork.

, 2018
To determine if proteasome inhibition using MG132 increased the efficiency of FIV vector-mediated transduction in human trabecular meshwork (TM)-1 cells and monkey organ-cultured anterior segments (MOCAS)
Larsen, I.V., Herrnberger, L., Sheridan, Rachael T. C., Gabelt, B'Ann T., Brandt, Curtis R, Ernst R. Tamm, Slauson, Sarah R, Sheridan, R.T.C., Curtis R. Brandt, Slauson, Sarah R., Aktas, Zeynep, Brandt, C.R., Kaufman, Paul L, Rao, Hongyu, Sarah R. Slauson, Aktas, Z., Brandt, Curtis R., Kaufman, Paul L., Tamm, E.R., Slauson, S.R., B'Ann T. Gabelt, Larsen, Inna V, Tamm, Ernst R, Tamm, Ernst R., Gabelt, B'Ann T, Herrnberger, Leonie, Gabelt, B.T., Hongyu Rao, Rao, H., Inna V. Larsen, Rachael T. C. Sheridan, Paul L. Kaufman, Larsen, Inna V., Sheridan, Rachael T C, Zeynep Aktas, Leonie Herrnberger, Kaufman, P.L.   +36 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source