Results 241 to 250 of about 3,447,958 (308)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Palladium-catalysed synthesis of small-molecule epigenetic inhibitors as anticancer therapeutics. [PDF]

J Enzyme Inhib Med Chem
Sharma R, Rana M, Thakur A, Ojha R, Mousavi SM, Dhingra A, Nepali K.   +6 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Cadonilimab plus chemotherapy <i>vs</i>. PD-1 inhibitor plus chemotherapy as first-line treatment for advanced gastric or gastroesophageal junction cancer with PD-L1 combined positive score <5: a propensity-matched, retrospective cohort study. [PDF]

J Gastrointest Oncol
Zhao D, Wu Z, Huang Y, Zhang L, Yuan X, Zhang N, Wei Q, Li J, Ying J, Xu Q.   +9 more
europepmc   +1 more source

Sequential use of PI3K/AKT/mTOR pathway inhibitors alpelisib and everolimus in patients with hormone receptor-positive metastatic breast cancer. [PDF]

Breast Cancer Res
Shen S, Teysir J, Safonov A, Bromberg M, Chen Y, Ahmed M, Razavi P, Jhaveri K.   +7 more
europepmc   +1 more source

Package Insert Warnings and Liver Function Tests for CDK4/6 Inhibitors for Breast Cancer.

JAMA Netw Open
Beachler DC, Lo Re V, Lanes S.
europepmc   +1 more source

Efficacy of SGLT2 Inhibitors on Clinical Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. [PDF]

Endocrinol Diabetes Metab
Daniyal SM, Khatoon NM, Rasool A, Gul I, Tabish S, Asifa S, Khalid A, Aftab Z, Burhan M, Fahim SL, Gondal HT, Nadir MA, Ahmed SZ, Ashraf DA, Ahmed S.   +14 more
europepmc   +1 more source

Treatment gaps in guideline-directed medical therapy for HFrEF in Singapore: findings from a multicentre retrospective cohort study. [PDF]

BMJ Open
Senanayake S, Lee ASY, Graves N, Win PPS, Lee A, Lau YH, Hausenloy DJ, Yeo KK, Chan MY, Wong RCC, Loh SY, Sim KLD, Chow W, Tan KB, Kularatna S.   +14 more
europepmc   +1 more source

Cyclic GMP-AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress. [PDF]

Hepatol Commun
Babuta M, Datta AA, de Carvalho Ribeiro M, Santos BACD, Morel C, Copeland C, Ortega-Ribera M, Mehta J, Calenda C, Wang Y, Remotti V, Brezani V, Patel A, Hawryluk D, Szabo G.   +14 more
europepmc   +1 more source