Results 231 to 240 of about 2,714,339 (309)

Inhibition of NHE1 Overcomes Temozolomide-Resistance in Glioblastoma via ROS-AKT/ERK Axis-Mediated Autophagy Suppression. [PDF]

J Biochem Mol Toxicol
Li D, Li Y, Zheng X, Wang Z, Wang Y, Zhang J, Guo J, Wang L, Li J, Liu Y, Li Y.   +10 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Conformational asymmetry of human immunodeficiency virus-1 protease flaps increases along the darunavir drug resistance pathway. [PDF]

Protein Sci
Guerrero M, Zadorozhnyi R, Lin G, Quinn CM, Calero G, Kurt-Yilmaz N, Schiffer CA, Polenova T, Gronenborn AM, Ishima R.   +9 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Multisite lichen planopilaris, oral lichen planus, and vulvar lichen sclerosus treated using Janus kinase inhibitors. [PDF]

Int J Womens Dermatol
Paz M, Ezzat RZ, Kreytak C, Senna MM.
europepmc   +1 more source

An evaluation of the N₂O emission reduction potential of enhanced efficiency nitrogen fertilizers and application timing in a semi-arid cereal cropping system. [PDF]

J Environ Qual
Daly E, Ogilvie C, Lemke RL, Farrell RE.
europepmc   +1 more source