Results 241 to 250 of about 2,714,339 (309)
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A metalloproteinase inhibitor as an inhibitor of neovascularization
Journal of Cellular Biochemistry, 1991AbstractMetalloproteinases and their endogenous inhibitors are key components of an enzyme system which is important in a number of fundamental biochemical and cellular processes. Our recent work has focused on the role of a particular metalloproteinase, collagenase, and the role of an endogenous inhibitor of this enzyme in the control of ...
M A, Moses, R, Langer
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Pharmaceutical Research, 1987
Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Farnesyltransferase inhibitors versus Ras inhibitors
Current Opinion in Chemical Biology, 1997Over the past few years, the idea that farnesyl-protein transferase (FPTase) inhibitors might be effective antiproliferative/antitumor agents has been realized in studies of cultured cells and in rodent models of cancer. Most of the studies with FPTase inhibitors have focused on inhibiting the growth of ras-transformed cells in vitro or the growth of ...
J B, Gibbs +6 more
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Enzymatic Inhibitors (Protease inhibitors, Amylase inhibitors, Cholinesterase Inhibitors)
2022Varun Kumar, Kanwate Balaji
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Aromatase inhibitors ? mechanisms of steroidal inhibitors
Breast Cancer Research and Treatment, 1994Inhibition of aromatase has been an attractive approach for examining the roles of estrogen biosynthesis in various physiological or pathological processes. Effective aromatase inhibitors can serve as potential therapeutic agents for controlling estrogen-dependent diseases such as hormone-dependent breast cancer.
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a-GLUCOSIDASE INHIBITOR, INVERTASE INHIBITOR, AND SUGAR ABSORPTION INHIBITOR
2021TAGA ATSUSHI +2 more
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Clinical Development of BRAF plus MEK Inhibitor Combinations
Trends in Cancer, 2020John M Kirkwood +2 more
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