Results 201 to 210 of about 7,577,140 (312)

Chemical Constituents of the Endophytic Fungus Purpureocillium lilacinum and Their Osteoclast Inhibitory Activity. [PDF]

Chem Biodivers
Fang SY, Nong XH, Guo YQ, Zou ZB, Huang XF, Xie CL, Yang XW.   +6 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Ephedrae Herba as a potential source of SARS-CoV-2 RNA-dependent RNA polymerase inhibitory activity. [PDF]

Front Pharmacol
Kiba Y, Hayashi T, Ando H, Kamauchi H, Yokogawa T, Suzuki R, Tanikawa T, Kitamura M.   +7 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Chemical Constituents of Deep-Sea-Derived Fungus Penicillium citrinum W17 and Their Ferroptosis Inhibitory Activity. [PDF]

Chem Biodivers
Zhang AL, Zou ZB, Guo YQ, Su WS, Xie CL, Li LS, Gao CH, Yang XW.   +7 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

In Vitro Inhibitory Activity of Three Hospital Biocides Against Multidrug-Resistant Clinical Isolates: A Pilot Study From Morocco. [PDF]

Cureus
Benaissa E, Amal Z, Hnach N, Ben Lahlou Y, Chadli M.   +4 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Ameliorative Effects of a Naphthoquinone Derivative With β-Amyloid Aggregation Inhibitory Activity on Cognitive Impairment and Metabolite Analysis of the Blood and Brains of Mice. [PDF]

Drug Dev Res
Oh JM, Jeong WK, Son HJ, Kim SY, Oh TW, Ji M, Nam JW, Baek M, Park JH, Shin WH, Kim HJ, Choi B, Paik MJ, Kim H.   +13 more
europepmc   +1 more source