Results 201 to 210 of about 1,997,109 (329)

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.

Blood, 2010
A. Quintás-Cardama, K. Vaddi, Phillip C. C. Liu, T. Manshouri, Jun Li, P. Scherle, E. Caulder, X. Wen, Yanlong Li, P. Waeltz, M. Rupar, T. Burn, Y. Lo, J. Kelley, M. Covington, Stacey Shepard, J. Rodgers, P. Haley, H. Kantarjian, J. Fridman, S. Verstovsek   +20 more
semanticscholar   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Phytochemical Composition and Antipseudomonal Activity of <i>Allanblackia gabonensis</i> (Clusiaceae) Extracts Alone and With Antibiotics Against Drug-Resistant Clinical Isolates. [PDF]

Scientifica (Cairo)
Sonfack CB, Fankam AG, Tiwa BN, Kengne MF, Mbaveng AT, Kuete V.   +5 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Invasive Argemone mexicana's suppressive effects on germination and early growth of Triticum aestivum and Hordeum vulgare in South-western Saudi Arabia. [PDF]

PLoS One
Alshaqhaa MA, Souid I, Alshehri MD, Alyahya N, Msaada K, Guedri MM.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Bioactivities of <i>Alchemilla alpina</i> L. Extract on Women's Reproductive and Metabolic Health: Antioxidant, Enzyme Inhibitory, Receptor Modulatory Properties and Potential Cytotoxic Effects. [PDF]

Int J Mol Sci
Krstić S, Bekić S, Živanović N, Pirković A, Vuković J, Bauer R, Rašeta M.   +6 more
europepmc   +1 more source

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

Molecular and Cellular Biology, 1994
B. Cheatham, C. Vlahos, L. Cheatham, Lois Wang, J. Blenis, C. Kahn   +5 more
semanticscholar   +1 more source

Determination of Half-Maximal Inhibitory Concentration (IC₅₀) of Drugs Using Contrast Surface Plasmon Imaging on Gold-Coated Periodic Nanowires

Analytical Chemistry
Hsien-San Hou, Kuang-Li Lee, Ting-Jui Tu, Ji-Yen Cheng, Pei-Kuen Wei   +4 more
openaire   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source