First-passage-time statistics of growing microbial populations carry an imprint of initial conditions. [PDF]
Sci Rep, 2023 Jones EW +4 more
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Author Correction: On the generation of internal waves by river plumes in subcritical initial conditions. [PDF]
Sci Rep, 2023 Mendes R +6 more
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A deep learning approach to estimating initial conditions of Brain Network Models in reference to measured fMRI data. [PDF]
Front Neurosci, 2023 Kashyap A, Plis S, Ritter P, Keilholz S.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
EcosphereEcosystems around the globe are experiencing changes in both the magnitude and fluctuations of environmental conditions due to land use and climate change.
Heather L. Wander +5 more
doaj +1 more source
Initial conditions and functioning over time among community coalitions. [PDF]
Eval Program Plann, 2022 Brown LD, Wells R, Chilenski SM.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Preparing to move: Setting initial conditions to simplify interactions with complex objects. [PDF]
PLoS Comput Biol, 2021 Nayeem R +4 more
europepmc +1 more source