Results 101 to 110 of about 47,693 (267)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Review on the Impact of Fallback Factor on Intermittent Gas and Gas-Assisted Plunger Lifts

Geosciences
In intermittent gas lift (IGL), not all the liquid initially in the tubing is usually produced at the surface in one cycle. This is due to a concept known as fallback, which occurs when some amount of the initial liquid column drops back to join the next
Erasmus Mensah, Smith Leggett
doaj   +1 more source

Lifting the Veil of Darkness: Thermal Technology Facilitates Collection of Flight‐Initiation Distances by Night

Ecology and Evolution
ABSTRACTFlight‐Initiation Distance (FID)—a direct measure of an individual animal's escape response—is a widely used method to study escape ecology in fauna. The technique has primarily been applied to bird species that are active by day. Indexing the escape behaviour of nocturnal species has been limited due to the need for light to detect and observe
Anthony R. Rendall, Roan D. Plotz, Kaori Yokochi, Joel Krauss, Aaron Pengelly, Sam A. Di Stefano, Sarah Swindell, Kithsiri Ranawana, Dulan R. Vidanapathirana, Michael A. Weston   +9 more
openaire   +3 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Closed (hydrodynamic) versus open (lateral sinus floor) subantral augmentation for single tooth replacement: criteria of decision-making and clinical efficacy

Journal of Oral Medicine and Oral Surgery
Introduction: This research aimed to study the impact of initial anatomical conditions on decision-making for subantral augmentation in a single tooth gap and to compare the clinical efficiency of closed hydrodynamic sinus lift and lateral sinus floor ...
Artemchuk Artem, Yahodka Bohdan, Osmanov Bekir, Kopchak Andrii, Chepurnyi Yurii   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Initial outcomes and surgical techniques of prostatic urethral lift for benign prostatic hyperplasia in Japan

International Journal of Urology
ObjectivesThe prostatic urethral lift (PUL) has been used as a minimally invasive surgery for benign prostatic hyperplasia (BPH) since April 2022 in Japan. This study evaluated the initial outcomes and surgical techniques of PUL for BPH.MethodsIn this prospective, single‐center study, indications were based on the proper use guidelines for PUL in Japan.
Go Anan, Kanya Kaga, Yosuke Fujishima, Hidero Minami, Thomas Mueller, David Sussman   +5 more
openaire   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source