Results 161 to 170 of about 1,168,780 (297)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

The Initial Mass Function Based on the Full-sky 20 pc Census of ∼3600 Stars and Brown Dwarfs

The Astrophysical Journal Supplement Series
A complete accounting of nearby objects—from the highest-mass white dwarf progenitors down to low-mass brown dwarfs—is now possible, thanks to an almost complete set of trigonometric parallax determinations from Gaia, ground-based surveys, and Spitzer ...
J. Davy Kirkpatrick, Federico Marocco, Christopher R. Gelino, Yadukrishna Raghu, Jacqueline K. Faherty, Daniella C. Bardalez Gagliuffi, Steven D. Schurr, Kevin Apps, Adam C. Schneider, Aaron M. Meisner, Marc J. Kuchner, Dan Caselden, R. L. Smart, S. L. Casewell, Roberto Raddi, Aurora Kesseli, Nikolaj Stevnbak Andersen, Edoardo Antonini, Paul Beaulieu, Thomas P. Bickle, Martin Bilsing, Raymond Chieng, Guillaume Colin, Sam Deen, Alexandru Dereveanco, Katharina Doll, Hugo A. Durantini Luca, Anya Frazer, Jean Marc Gantier, Léopold Gramaize, Kristin Grant, Leslie K. Hamlet, Hiro Higashimura, Michiharu Hyogo, Peter A. Jałowiczor, Alexander Jonkeren, Martin Kabatnik, Frank Kiwy, David W. Martin, Marianne N. Michaels, William Pendrill, Celso Pessanha Machado, Benjamin Pumphrey, Austin Rothermich, Rebekah Russwurm, Arttu Sainio, John Sanchez, Fyodor Theo Sapelkin-Tambling, Jörg Schümann, Karl Selg-Mann, Harshdeep Singh, Andres Stenner, Guoyou Sun, Christopher Tanner, Melina Thévenot, Maurizio Ventura, Nikita V. Voloshin, Jim Walla, Zbigniew Wędracki, Jose I. Adorno, Christian Aganze, Katelyn N. Allers, Hunter Brooks, Adam J. Burgasser, Emily Calamari, Thomas Connor, Edgardo Costa, Peter R. Eisenhardt, Jonathan Gagné, Roman Gerasimov, Eileen C. Gonzales, Chih-Chun Hsu, Rocio Kiman, Guodong Li, Ryan Low, Eric Mamajek, Blake M. Pantoja, Mark Popinchalk, Jon M. Rees, Daniel Stern, Genaro Suárez, Christopher Theissen, Chao-Wei Tsai, Johanna M. Vos, David Zurek, (The Backyard Worlds: Planet 9 Collaboration)   +85 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Initial Mass Distribution For Exoplanetary Systems

, 2012
International audienceThe initial mass distribution for exoplanet systems, prior to the onset of planet-planet scattering, has yet to be adequately constrained.
Gorelick, N., Barnes, R., Timpe, Miles L., Raymond, Sean N.   +3 more
core   +2 more sources

A Census of the β Pic Moving Group and Other Nearby Associations with Gaia

The Astronomical Journal
I have used the third data release of the Gaia mission to improve the reliability and completeness of membership samples in the β Pic moving group (BPMG) and other nearby associations with ages of 20–50 Myr (Sco Body, Carina, Columba, χ ^1 For, Tuc-Hor ...
K. L. Luhman
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source