Results 151 to 160 of about 1,168,780 (297)

The origin of the initial mass function

, 2007
We review recent advances in our understanding of the origin of the initial mass function (IMF). We emphasize the use of numerical simulations to investigate how each physical process involved in star formation affects the resulting IMF.
Ian A. Bonnell, Richard B. Larson, Hans Zinnecker   +2 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Resolving the Mechanical and Radiative Feedback in J1044+0353 with Keck Cosmic Web Imager Spectral Mapping

The Astrophysical Journal
We present integral field spectroscopy toward and around J1044+0353, a rapidly growing, low-metallicity galaxy that produces extreme [O iii ] line emission.
Crystal L. Martin, Zixuan Peng, Yuan Li
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The Initial Mass Function of Stars and Brown Dwarfs in the Upper Sco Association

The Astronomical Journal
I present infrared spectroscopy of 37 brown dwarf candidates in the Upper Scorpius (Upper Sco) association, 35 of which are classified as young and cool, making them likely members.
K. L. Luhman
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The Panchromatic Hubble Andromeda Treasury: Triangulum Extended Region (PHATTER). VI. The High-mass Stellar Initial Mass Function of M33

The Astronomical Journal
We measure the high-mass stellar initial mass function (IMF) from resolved stars in M33 young stellar clusters. Leveraging the Hubble Space Telescope’s high resolving power, we fully model the IMF probabilistically.
Tobin M. Wainer, Benjamin F. Williams, L. Clifton Johnson, Daniel R. Weisz, Julianne J. Dalcanton, Anil C. Seth, Andrew Dolphin, Meredith J. Durbin, Eric F. Bell, Zhuo Chen, Puragra Guhathakurta, Eric W. Koch, Christina W. Lindberg, Erik Rosolowsky, Karin M. Sandstrom, Evan D. Skillman, Adam Smercina, Estephani E. TorresVillanueva   +17 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Experimental research on low and strength characteristics of coal slime based cemented filling material

Meitan kexue jishu
To study the flow and strength characteristics of coal slime based backfill materials, orthogonal tests were used to design one cemented backfill material combining coal slime, high-water-content materials, cement, and fly ash.
Baifu AN, Qiaomei YI, Xiang ZHAO, Weijian YU, Dongda WANG, Jiale WANG   +5 more
doaj   +1 more source