Results 131 to 140 of about 3,434,376 (288)

The Stellar Initial Mass Function down To 0.16 M⊙ toward the Small Magellanic Cloud

The Astrophysical Journal
The presence (and nature) of variations in the stellar initial mass function (IMF) at substantially subsolar masses and metallicities ( m < 0.5 M _⊙ and [M/H] ≲ −1, respectively) remains poorly constrained. Predictions from simulations vary widely, while
Roger E. Cohen, Mario Gennaro, Matteo Correnti, Kristen B. W. McQuinn, Vedant Chandra   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Initial Mass Function of Stars and Brown Dwarfs in the Upper Sco Association

The Astronomical Journal
I present infrared spectroscopy of 37 brown dwarf candidates in the Upper Scorpius (Upper Sco) association, 35 of which are classified as young and cool, making them likely members.
K. L. Luhman
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Investigations of Massive Filaments and Star Formation (INFANT). I. Core Identification and Core Mass Function

The Astrophysical Journal
Filamentary structures are ubiquitously found in high-mass star-forming clouds. To investigate the relationship between filaments and star formation, we carry out the INFANT (Investigations of Massive Filaments and Sar Formation) survey, a multiscale ...
Yu Cheng, Xing Lu, Patricio Sanhueza, Hauyu Baobab Liu, Qizhou Zhang, Roberto Galván-Madrid, Ke Wang, Fumitaka Nakamura, Tie Liu, Siyi Feng, Shanghuo Li, Sihan Jiao, Kei E. I. Tanaka, Xunchuan Liu, Pak Shing Li, Qiuyi Luo, Qilao Gu, Yuxin Lin, Andrés E. Guzmán   +18 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

First Detection of CO Isotopologues in a High-redshift Main-sequence Galaxy: Evidence of a Top-heavy Stellar Initial Mass Function

The Astrophysical Journal
Recent observations and theories have presented a strong challenge to the universality of the stellar initial mass function (IMF) in extreme environments. A notable example has been found for starburst conditions, where evidence favors a top-heavy IMF, i.
Ziyi Guo, Zhi-Yu Zhang, Zhiqiang Yan, Eda Gjergo, Allison W. S. Man, R. J. Ivison, Xiaoting Fu, Yong Shi   +7 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Resolving the Mechanical and Radiative Feedback in J1044+0353 with Keck Cosmic Web Imager Spectral Mapping

The Astrophysical Journal
We present integral field spectroscopy toward and around J1044+0353, a rapidly growing, low-metallicity galaxy that produces extreme [O iii ] line emission.
Crystal L. Martin, Zixuan Peng, Yuan Li
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source