Results 131 to 140 of about 11,541,392 (252)
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
The Initial Mass Function of Stars and Brown Dwarfs in the Upper Sco Association
The Astronomical JournalI present infrared spectroscopy of 37 brown dwarf candidates in the Upper Scorpius (Upper Sco) association, 35 of which are classified as young and cool, making them likely members.
K. L. Luhman
doaj +1 more source
The origin of the initial mass function
, 2007 We review recent advances in our understanding of the origin of the initial mass function (IMF). We emphasize the use of numerical simulations to investigate how each physical process involved in star formation affects the resulting IMF.
Ian A. Bonnell +2 more
core
Spectroscopic substellar initial mass function of NGC 2244
Funding: V.A-A., K.M. and K.K. acknowledge funding by the Science and Technology Foundation of Portugal (FCT), grants No. IF/00194/2015, PTDC/FIS-AST/28731/2017, UIDB/00099/2020, SFRH/BD/143433/2019 and PTDC/FIS-AST/7002/2020. R.S. acknowledges financial
Bayo, A. +12 more
core +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Computing the probability mass function of the maximum flow through a reliable network [PDF]
In this paper we propose a fast state-space enumeration based algorithm called TOP-DOWN capable of computing the probability mass function of the maximum s-t flow through reliable networks.
Sharma, Megha, Ghosh, Diptesh
core
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source