Results 111 to 120 of about 3,434,376 (288)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Local Stellar Initial Mass Function

, 2000
This contribution describes the difficult task of inferring the IMF from local star-count data, by discussing the mass-luminosity relation, unresolved binary, triple and quadruple systems, abundance and age spreads and Galactic structure, all of which must be accounted for properly for the results to be meaningful.
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Do Red Galaxies Form More Stars than Blue Galaxies?

The Astrophysical Journal
A new model is proposed in which typical galaxies form most of their stellar mass in a phase with an intrinsically red stellar population. In the standard picture, galaxies with intrinsically red stellar populations are believed to have old stellar ...
Charles L. Steinhardt
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Variation in the Galaxy-wide Initial Mass Function for Low-mass Stars: Modeling and Observational Insights

The Astrophysical Journal
The stellar initial mass function (IMF) characterizes the mass distribution of newly formed stars in various cosmic environments, serving as a fundamental assumption in astrophysical research. Recent findings challenge the prevalent notion of a universal
Zhiqiang Yan, Jiadong Li, Pavel Kroupa, Tereza Jerabkova, Eda Gjergo, Zhi-Yu Zhang   +5 more
doaj   +1 more source

Understanding the Stellar Initial Mass Function

, 2006
The essential features of the stellar Initial Mass Function are, rather generally, (1) a peak at a mass of a few tenths of a solar mass, and (2) a power-law tail toward higher masses that is similar to the original Salpeter function. Recent work suggests that the IMF peak reflects a preferred scale of fragmentation associated with the transition from a
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Exploring NGC 2345: A Comprehensive Study of a Young Open Cluster through Photometric and Kinematic Analysis

The Astronomical Journal
We conducted a photometric and kinematic analysis of the young open cluster NGC 2345 using CCD UBV data from 2 m Himalayan Chandra Telescope, Gaia Data Release 3, Two Micron All-Sky Survey, and the Photometric All-Sky Survey data sets. We found 1732 most
Kuldeep Belwal, D. Bisht, Mohit Singh Bisht, Geeta Rangwal, Ashish Raj, Arvind K. Dattatrey, R. K. S. Yadav, B. C. Bhatt   +7 more
doaj   +1 more source

The Initial Mass Function of Stars

, 2006
Observations and theory of the IMF are briefly reviewed. Slight variations have been observed, although they are difficult to prove unambiguously. Most detailed theoretical models reproduce the IMF, but because they use different assumptions and conditions, there is no real convergence of explanations yet.
openaire   +2 more sources