Results 111 to 120 of about 1,168,780 (297)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Planet Mass Function around M Stars at 1–10 au: A Plethora of Sub-Earth Mass Objects
The Astrophysical JournalSmall planets (≲1 M _⊕ ) at intermediate orbital distances (∼1 au) represent an uncharted territory in exoplanetary science. The upcoming microlensing survey by the Nancy Grace Roman Space Telescope will be sensitive to objects as light as Ganymede and ...
Yayaati Chachan, Eve J. Lee
doaj +1 more source
The initial mass function in HII galaxies
, 1987 Observation of a large sample of HII galaxies shows that the emission line ratios of the youngest objects change systematically with gaseous oxygen abundance, which was interpreted as resulting from changes in the initial mass function (IMF) of the ...
Campbell, Alison W.
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
eta Chamaeleontis: abnormal initial mass function or dynamical evolution?
, 2007 International audienceContext: η Chamaeleontis is a unique young (~9 Myr) association with 18 systems concentrated in a radius of ≈35 arcmin, i.e. 1 pc at the cluster distance of 97 pc.
C. Clarke +5 more
core +1 more source
ON THE INITIAL CONDITIONS FOR STAR FORMATION AND THE INITIAL MASS FUNCTION [PDF]
The Astrophysical Journal, 2011 Density probability distribution functions (PDFs) for turbulent self-gravitating clouds should be convolutions of the local log-normal PDF, which depends on the local average density ρave and Mach number , and the PDFs for ρave and , which depend on the overall cloud structure.
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Do Red Galaxies Form More Stars than Blue Galaxies?
The Astrophysical JournalA new model is proposed in which typical galaxies form most of their stellar mass in a phase with an intrinsically red stellar population. In the standard picture, galaxies with intrinsically red stellar populations are believed to have old stellar ...
Charles L. Steinhardt
doaj +1 more source
On the Mass Distribution of Stellar-Mass Black Holes
Open Astronomy, 2014 The observational stellar-mass black hole mass distribution exhibits a maximum at about 8 M⊙. It can be explained via the details of the massive star evolution, supernova explosions, or consequent black hole evolution.
Malkov O. Yu.
doaj +1 more source
Mapping the core mass function on to the stellar initial mass function: multiplicity matters [PDF]
, 2013 Observations indicate that the central portions of the present-day prestellar core mass function (hereafter CMF) and the stellar initial mass function (hereafter IMF) both have approximately log-normal shapes, but that the CMF is displaced to higher ...
Goodwin, S.P. +10 more
core +1 more source