Results 91 to 100 of about 11,541,392 (252)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Do Red Galaxies Form More Stars than Blue Galaxies?
The Astrophysical JournalA new model is proposed in which typical galaxies form most of their stellar mass in a phase with an intrinsically red stellar population. In the standard picture, galaxies with intrinsically red stellar populations are believed to have old stellar ...
Charles L. Steinhardt
doaj +1 more source
, 2012 We highlight the impact of cluster-mass-dependent evolutionary rates upon the evolution of the cluster mass function during violent relaxation, that is, while clusters dynamically respond to the expulsion of their residual star-forming gas.
Parmentier, Genevieve, Baumgardt, Holger
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Quantifying Element Importance for Mass Recovery from Population III Supernova Yield Fits
The Astrophysical JournalMassive Population III (Pop III) stars are currently not observed, but their initial mass function (IMF) can be inferred through stellar archaeology: by fitting core-collapse supernova yield models to elemental abundances of low-mass, long-lived metal ...
Zhongyuan Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Astrophysical JournalEruptive accretion events are expected to play an important role in the mass-buildup stage of individual star formation. FU Ori objects (FUors) experience the most extreme eruptive outbursts, which raise the accretion rate of the disk from 10 ^−9 –10 ^−8
Adolfo S. Carvalho, Lynne A. Hillenbrand
doaj +1 more source
Many studies have revealed that the core mass function (CMF) in high-mass star-forming regions is top-heavy. In this work, we start from the canonical initial mass function (IMF) to inversely synthesize the observed CMFs of high-mass star formation ...
Sami Dib, Pavel Kroupa, J. W. Zhou
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The fragmentation properties of massive star-forming regions in 30Dor-10 at 2000 au resolution
Nature CommunicationsThe fragmentation properties of parsec- scale clumps play a fundamental role in shaping the dense gas condensations known as cores, the immediate progenitor of stars.
Alessio Traficante +11 more
doaj +1 more source