Results 101 to 110 of about 11,541,392 (252)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Variation of the low-mass end of the stellar initial mass function with redshift and metallicity (article) [PDF]

We report the stellar mass functions obtained from 20 radiation hydrodynamical simulations of star cluster formation in 500 Msun molecular clouds with metallicities of 3, 1, 1/10 and 1/100 of the solar value, with the clouds subjected to levels of the ...
MR Bate (21849113)
core   +3 more sources

The Variation in the Galaxy-wide Initial Mass Function for Low-mass Stars: Modeling and Observational Insights

The Astrophysical Journal
The stellar initial mass function (IMF) characterizes the mass distribution of newly formed stars in various cosmic environments, serving as a fundamental assumption in astrophysical research. Recent findings challenge the prevalent notion of a universal
Zhiqiang Yan, Jiadong Li, Pavel Kroupa, Tereza Jerabkova, Eda Gjergo, Zhi-Yu Zhang   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Exploring NGC 2345: A Comprehensive Study of a Young Open Cluster through Photometric and Kinematic Analysis

The Astronomical Journal
We conducted a photometric and kinematic analysis of the young open cluster NGC 2345 using CCD UBV data from 2 m Himalayan Chandra Telescope, Gaia Data Release 3, Two Micron All-Sky Survey, and the Photometric All-Sky Survey data sets. We found 1732 most
Kuldeep Belwal, D. Bisht, Mohit Singh Bisht, Geeta Rangwal, Ashish Raj, Arvind K. Dattatrey, R. K. S. Yadav, B. C. Bhatt   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Tails of Gravity: Persistence of Star Formation in the Central Molecular Zone

The Astrophysical Journal
We characterize star-forming gas in six molecular clouds (Sgr B1-off, Sgr B2, Sgr C, the 20 and 50 km s ^−1 molecular clouds, and the Brick) in the Galactic central molecular zone (CMZ), and compare their star-forming activities with those in molecular ...
Linjing Feng, Sihan Jiao, Fengwei Xu, Hauyu Baobab Liu, Xing Lu, Neal J. Evans II, Elisabeth A.C. Mills, Attila Kovács, Qizhou Zhang, Yuxin Lin, Jingwen Wu, Chao-Wei Tsai, Di Li, Zhi-Yu Zhang, Zhiqiang Yan, Hao Ruan, Fangyuan Deng, Yuanzhen Xiong, Ruofei Zhang   +18 more
doaj   +1 more source

eta Chamaeleontis: abnormal initial mass function or dynamical evolution?

, 2007
International audienceContext: η Chamaeleontis is a unique young (~9 Myr) association with 18 systems concentrated in a radius of ≈35 arcmin, i.e. 1 pc at the cluster distance of 97 pc.
C. Clarke, W. A. Lawson, Clarke, C., Moraux, E., E. Moraux, Lawson, W. A.   +5 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

The Physical Origin of the Stellar Initial Mass Function [PDF]

Stars are amongst the most fundamental structures of our Universe. They comprise most of the baryonic and luminous mass of galaxies, synthethise heavy elements, and injec\ t mass, momentum, and energy into the interstellar medium.
Grudić, Michael Y., Hennebelle, Patrick
core   +1 more source