Results 121 to 130 of about 11,541,392 (252)

Astronomy Astrophysics The relationship between the prestellar core mass function and the stellar initial mass function

, 2008
Stars form from dense molecular cores, and the mass function of these cores (the CMF) is often found to be similar to the form of the stellar initial mass function (IMF).
P Kroupa, D Nutter, D Ward-Thompson, S P Goodwin, A P Whitworth   +4 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Investigations of Massive Filaments and Star Formation (INFANT). I. Core Identification and Core Mass Function

The Astrophysical Journal
Filamentary structures are ubiquitously found in high-mass star-forming clouds. To investigate the relationship between filaments and star formation, we carry out the INFANT (Investigations of Massive Filaments and Sar Formation) survey, a multiscale ...
Yu Cheng, Xing Lu, Patricio Sanhueza, Hauyu Baobab Liu, Qizhou Zhang, Roberto Galván-Madrid, Ke Wang, Fumitaka Nakamura, Tie Liu, Siyi Feng, Shanghuo Li, Sihan Jiao, Kei E. I. Tanaka, Xunchuan Liu, Pak Shing Li, Qiuyi Luo, Qilao Gu, Yuxin Lin, Andrés E. Guzmán   +18 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

First Detection of CO Isotopologues in a High-redshift Main-sequence Galaxy: Evidence of a Top-heavy Stellar Initial Mass Function

The Astrophysical Journal
Recent observations and theories have presented a strong challenge to the universality of the stellar initial mass function (IMF) in extreme environments. A notable example has been found for starburst conditions, where evidence favors a top-heavy IMF, i.
Ziyi Guo, Zhi-Yu Zhang, Zhiqiang Yan, Eda Gjergo, Allison W. S. Man, R. J. Ivison, Xiaoting Fu, Yong Shi   +7 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Resolving the Mechanical and Radiative Feedback in J1044+0353 with Keck Cosmic Web Imager Spectral Mapping

The Astrophysical Journal
We present integral field spectroscopy toward and around J1044+0353, a rapidly growing, low-metallicity galaxy that produces extreme [O iii ] line emission.
Crystal L. Martin, Zixuan Peng, Yuan Li
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The Stellar Initial Mass Function down To 0.16 M⊙ toward the Small Magellanic Cloud

The Astrophysical Journal
The presence (and nature) of variations in the stellar initial mass function (IMF) at substantially subsolar masses and metallicities ( m < 0.5 M _⊙ and [M/H] ≲ −1, respectively) remains poorly constrained. Predictions from simulations vary widely, while
Roger E. Cohen, Mario Gennaro, Matteo Correnti, Kristen B. W. McQuinn, Vedant Chandra   +4 more
doaj   +1 more source