Results 121 to 130 of about 1,168,780 (297)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Astrophysical JournalEruptive accretion events are expected to play an important role in the mass-buildup stage of individual star formation. FU Ori objects (FUors) experience the most extreme eruptive outbursts, which raise the accretion rate of the disk from 10 ^−9 –10 ^−8
Adolfo S. Carvalho, Lynne A. Hillenbrand
doaj +1 more source
Wide binary stars in the Galactic field : a statistical approach [PDF]
, 2010 This thesis focuses on the statistical properties of wide binary (WB) star systems in the Galactic field. With projected separations larger than 200 AU and, consequently, having very low binding energies, WB are sensitive probes of the Galactic ...
Longhitano, Marco
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The Astrophysical JournalThe stellar initial mass function (IMF) characterizes the mass distribution of newly formed stars in various cosmic environments, serving as a fundamental assumption in astrophysical research. Recent findings challenge the prevalent notion of a universal
Zhiqiang Yan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Quantifying Element Importance for Mass Recovery from Population III Supernova Yield Fits
The Astrophysical JournalMassive Population III (Pop III) stars are currently not observed, but their initial mass function (IMF) can be inferred through stellar archaeology: by fitting core-collapse supernova yield models to elemental abundances of low-mass, long-lived metal ...
Zhongyuan Zhang +3 more
doaj +1 more source
The Luminosity Function and Initial Mass Function in the Galactic Bulge [PDF]
, 1998 We present deep photometry obtained with the Hubble Space Telescope in a field in Baade's window in the Galactic bulge. We derive a luminosity function down to I ~ 24.3, or V ~ 27.5, corresponding to M ~ 0.3 M_☉.
Light, Robert M. +7 more
core
Crucial aspects of the initial mass function
, 2013 Context. In a probabilistic framework of the interpretation of the initial mass function (IMF), the IMF cannot be arbitrarily normalized to the total mass, ℳ, or number of stars, N, of the system.
Sánchez, Néstor +11 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source