Results 181 to 190 of about 4,577,009 (388)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The Panchromatic Hubble Andromeda Treasury: Triangulum Extended Region (PHATTER). VI. The High-mass Stellar Initial Mass Function of M33

The Astronomical Journal
We measure the high-mass stellar initial mass function (IMF) from resolved stars in M33 young stellar clusters. Leveraging the Hubble Space Telescope’s high resolving power, we fully model the IMF probabilistically.
Tobin M. Wainer, Benjamin F. Williams, L. Clifton Johnson, Daniel R. Weisz, Julianne J. Dalcanton, Anil C. Seth, Andrew Dolphin, Meredith J. Durbin, Eric F. Bell, Zhuo Chen, Puragra Guhathakurta, Eric W. Koch, Christina W. Lindberg, Erik Rosolowsky, Karin M. Sandstrom, Evan D. Skillman, Adam Smercina, Estephani E. TorresVillanueva   +17 more
doaj   +1 more source

The Dynamical Evolution of Expanding HI Shells and Initial Mass Function of OB Associations [PDF]

, 1986
Sergiy Silich
openalex   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

The initial mass function in HII galaxies [PDF]

Observation of a large sample of HII galaxies shows that the emission line ratios of the youngest objects change systematically with gaseous oxygen abundance, which was interpreted as resulting from changes in the initial mass function (IMF) of the ...
Campbell, Alison W.
core   +1 more source

Experimental research on low and strength characteristics of coal slime based cemented filling material

Meitan kexue jishu
To study the flow and strength characteristics of coal slime based backfill materials, orthogonal tests were used to design one cemented backfill material combining coal slime, high-water-content materials, cement, and fly ash.
Baifu AN, Qiaomei YI, Xiang ZHAO, Weijian YU, Dongda WANG, Jiale WANG   +5 more
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

The Stellar Initial Mass Function in Starburst Galaxies [PDF]

, 1999
Claus Leitherer
openalex   +1 more source